產(chǎn)品名稱

S-Propargyl-Cysteine - SPRC | ZYZ-802

產(chǎn)品貨號(hào)

Axon 2666 CAS [3262-64-4] MF C6H9NO2SMW 159.21 Purity: 98% Optical purity: Optically pure Soluble in water Description S-Propargyl-cysteine (SPRC), a substrate of cystathionine γ-lyase (CSE), is a water-soluble modulator of endogenous hydrogen disulfide (H2S). SPRC is a potential agent for the treatment of Alzheimer’s disease (TNF signalling, the NF-κB pathway and the ERK1/2 pathway), anemia of inflammation (IL-6/JAK2/STAT3 pathway), ischemic heart disease (H2S/VEGFR2/STAT3 pathway) and myocardial infarction. KEYWORDS: S-Propargyl-Cysteine | supplier | H2S donor | SPRC | ZYZ-802 | S-Propargylcysteine | ZYZ802 | ZYZ 802 | CAS [3262-64-4] | L-cysteine | CSE | Activator | Enzymes

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axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

S-Propargyl-Cysteine - SPRC | ZYZ-802

Based on 5 reference(s) in Google Scholar 7 10 5

Axon 2666

CAS [3262-64-4]

MF C6H9NO2S
MW 159.21

Purity: 98%
Optical purity: Optically pure
Soluble in water

S-Propargyl-Cysteine

Description

S-Propargyl-cysteine (SPRC), a substrate of cystathionine γ-lyase (CSE), is a water-soluble modulator of endogenous hydrogen disulfide (H2S). SPRC is a potential agent for the treatment of Alzheimer’s disease (TNF signalling, the NF-κB pathway and the ERK1/2 pathway), anemia of inflammation (IL-6/JAK2/STAT3 pathway), ischemic heart disease (H2S/VEGFR2/STAT3 pathway) and myocardial infarction.

Q Wang et al. S-propargyl-cysteine protects both adult rat hearts and neonatal cardiomyocytes from ischemia/hypoxia injury: the contribution of the hydrogen sulfide-mediated pathway. J Cardiovasc Pharmacol. 2009 Aug;54(2):139-46.

QH Gong et al. S-propargyl-cysteine, a novel hydrogen sulfide-modulated agent, attenuates lipopolysaccharide-induced spatial learning and memory impairment: involvement of TNF signaling and NF-κB pathway in rats. Brain Behav Immun. 2011 Jan;25(1):110-9.

QH Gong et al. S-Propargyl-Cysteine (ZYZ-802), a Sulphur-Containing Amino Acid, Attenuates Beta-Amyloid-Induced Cognitive Deficits and Pro-Inflammatory Response: Involvement of ERK1/2 and NF-κB Pathway in Rats. Amino Acids. 2011 Feb;40(2):601-10.

J Kan et al. S-propargyl-cysteine, a novel water-soluble modulator of endogenous hydrogen sulfide, promotes angiogenesis through activation of signal transducer and activator of transcription 3. Antioxid Redox Signal. 2014 May 20;20(15):2303-16.

M Wang et al. S-Propargyl-Cysteine, a Novel Hydrogen Sulfide Donor, Inhibits Inflammatory Hepcidin and Relieves Anemia of Inflammation by Inhibiting IL-6/STAT3 Pathway. PLoS One. 2016 Sep 20;11(9):e0163289.

Certificate of Analysis
Material Safety Data Sheet

Angiogenesis Cardiovascular CNS NF-κB MAPK JAK-STAT CSE EC 4.4.1.1

Modulator of endogenous hydrogen disulfide

Chemical name

(R)-2-Amino-3-(prop-2-ynylthio)propanoic acid

Parent CAS No.

[3262-64-4]

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