產(chǎn)品名稱

NRX 194204 - IRX4204 | NRX 4204 | VTP 194204 | AGN 194204 | AGN 4204

產(chǎn)品貨號

Axon 2408 CAS [220619-73-8] MF C24H32O2MW 352.51 Purity: 99% Optical purity: Optically pure Soluble in DMSO Description Highly potent and specific RXR agonist (Kd values 0.4 nM, 3.6 nM, and 3.8 nM for RXRα, RXRβ, and RXRγ, respectively) devoid of any RAR activity (Kd values >30 μM for RARα, RARβ, and RARγ). NRX 194204 blocked the ability of lipopolysaccharide and TNFα to induce the release of nitric oxide and IL6 and the degradation of IKBα in RAW264.7 macrophage-like cells. NRX194204 prevents carcinogenesis in both the lung and mammary gland, and enhances the ability of ligands for PPARs or cytotoxic drugs, including cisplatin and 5-flurouracil, to inhibit proliferation and induce apoptosis in breast and pancreatic cancer cell lines. KEYWORDS: NRX 194204 | RXR agonist | NRX 4204 | VTP 194204 | AGN 194204 | AGN 4204 | NRX4204;NRX-4204; IRX 4204; IRX-4204 | NRX194204; NRX-194204 | VTP194204; VTP-194204 | AGN194204; AGN-194204 | AGN4204; AGN-4204 | CAS [220619-73-8] | Retinoic Acid | Retinoic Acid (RXR) | devoid | RAR | carcinogenesis | Agonist | Receptors

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

NRX 194204 - IRX4204 | NRX 4204 | VTP 194204 | AGN 194204 | AGN 4204

Based on 8 reference(s) in Google Scholar 9 10 8

Axon 2408

CAS [220619-73-8]

MF C24H32O2
MW 352.51

Purity: 99%
Optical purity: Optically pure
Soluble in DMSO

NRX 194204

Description

Highly potent and specific RXR agonist (Kd values 0.4 nM, 3.6 nM, and 3.8 nM for RXRα, RXRβ, and RXRγ, respectively) devoid of any RAR activity (Kd values >30 μM for RARα, RARβ, and RARγ). NRX 194204 blocked the ability of lipopolysaccharide and TNFα to induce the release of nitric oxide and IL6 and the degradation of IKBα in RAW264.7 macrophage-like cells. NRX194204 prevents carcinogenesis in both the lung and mammary gland, and enhances the ability of ligands for PPARs or cytotoxic drugs, including cisplatin and 5-flurouracil, to inhibit proliferation and induce apoptosis in breast and pancreatic cancer cell lines.

K. Liby et al. A new rexinoid, NRX194204, prevents carcinogenesis in both the lung and mammary gland. Clin Cancer Res. 2007 Oct 15;13(20):6237-43.

V. Vuligonda et al. Enantioselective syntheses of potent retinoid X receptor ligands: differential biological activities of individual antipodes. J Med Chem. 2001 Jul 5;44(14):2298-303.

R. AS Chandraratna et al. Treatment with retinoid X receptor agonist IRX4204 ameliorates experimental autoimmune encephalomyelitis. Am J Transl Res. 2016; 8(2): 1016–1026.

Certificate of Analysis
Material Safety Data Sheet

Apoptosis Cell Cycle Regulation Cell Signaling & Oncology Pain & Inflammation Retinoic Acid (RXR) NR2B

Highly potent and specific RXR agonist devoid of any RAR activity

Chemical name

(2E,4E)-3-Methyl-5-((1S,2S)-2-methyl-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydronaphthalen-2-yl)cyclopropyl)penta-2,4-dienoic acid

Parent CAS No.

[220619-73-8]

產(chǎn)品資料