| 產(chǎn)品名稱 | AMG 232 |
| 產(chǎn)品貨號 | Axon 2639 CAS [1352066-68-2] MF C28H35Cl2NO5SMW 568.55 Purity: 100% Optical purity: Optically pure Soluble in 0.1N NaOH(aq) and DMSO Description Potent, selective, and orally bioavailable MDM2-p53 inhibitor (IC50 value 9.1 nM, Kd 0.045 nM), demonstrating remarkable pharmacokinetic properties and in vivo antitumor activity in the SJSA-1 osteosarcoma xenograft model. Moreover, AMG 232 activates p53 pathway activity in vivo, and potentiates the activity of p53-inducing cytotoxic agents. KEYWORDS:?AMG 232 | supplier | MDM2 inhibitor | AMG232 | AMG-232 | CAS [1352066-68-2] | Axon Medchem | Axon 2639 | p53 | HDM-MDM | orally bioavailable | MDM2-p53 interaction | antitumor activity | SJSA-1 | osteosarcoma | xenograft model | p21 |
| 產(chǎn)品價格 | 現(xiàn)貨詢價，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
AMG 232Axon 2639 CAS [1352066-68-2] MF C28H35Cl2NO5S
DescriptionPotent, selective, and orally bioavailable MDM2-p53 inhibitor (IC50 value 9.1 nM, Kd 0.045 nM), demonstrating remarkable pharmacokinetic properties and in vivo antitumor activity in the SJSA-1 osteosarcoma xenograft model. Moreover, AMG 232 activates p53 pathway activity in vivo, and potentiates the activity of p53-inducing cytotoxic agents. KEYWORDS:?AMG 232 | supplier | MDM2 inhibitor | AMG232 | AMG-232 | CAS [1352066-68-2] | Axon Medchem | Axon 2639 | p53 | HDM-MDM | orally bioavailable | MDM2-p53 interaction | antitumor activity | SJSA-1 | osteosarcoma | xenograft model | p21
Potent, selective, and orally bioavailable MDM2-p53 inhibitor
Chemical name2-((3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-((S)-1-(isopropylsulfonyl)-3-methylbutan-2-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid Parent CAS No.[1352066-68-2] |
| 產(chǎn)品資料 |
