產(chǎn)品名稱

ZCZ 011

產(chǎn)品貨號

Axon 2543 CAS [1998197-39-9] MF C21H18N2O2SMW 362.44 Purity: 99% Soluble in DMSO Description Brain penetrant cannabinoid CB1 receptor positive allosteric modulator (PAM) which augments the in vitro and in vivo pharmacological actions of the CB1 orthosteric agonists CP55940 (pEC50 value 6.90) and N-arachidonoylethanolamine (AEA) and reduces neuropathic pain in the mouse with no psychoactive effects. KEYWORDS: ZCZ 011 | supplier | PAM of CB1 | ZCZ011 | CAS [1998197-39-9] | Cannabinoids | CB1 | PAM | positive allosteric modulator | brain penetrant | neuropathic pain

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

ZCZ 011

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 2543

CAS [1998197-39-9]

MF C21H18N2O2S
MW 362.44

Purity: 99%
Soluble in DMSO

ZCZ 011

Description

Brain penetrant cannabinoid CB1 receptor positive allosteric modulator (PAM) which augments the in vitro and in vivo pharmacological actions of the CB1 orthosteric agonists CP55940 (pEC50 value 6.90) and N-arachidonoylethanolamine (AEA) and reduces neuropathic pain in the mouse with no psychoactive effects.

BM Ignatowska-Jankowska et al. A Cannabinoid CB1 Receptor-Positive Allosteric Modulator Reduces Neuropathic Pain in the Mouse with No Psychoactive Effects. Neuropsychopharmacology. 2015 Dec;40(13):2948-59.

JL Poklis et al. HPLC-MS-MS Determination of ZCZ-011, A Novel Pharmacological Tool for Investigation of the Cannabinoid Receptor in Mouse Brain Using Clean Screen FASt? Column Extraction. J Anal Toxicol. 2015 Jun;39(5):353-8.

Certificate of Analysis
Material Safety Data Sheet

Cardiovascular CNS Diabetes & Metabolism Pain & Inflammation CB1 A13

Brain penetrant CB1 positive allosteric modulator (PAM)

Chemical name

6-methyl-3-(2-nitro-1-(thiophen-2-yl)ethyl)-2-phenyl-1H-indole

Parent CAS No.

[1998197-39-9]

產(chǎn)品資料