產(chǎn)品名稱

Eact

產(chǎn)品貨號(hào)

Axon 2576 CAS [461000-66-8] MF C22H24N2O5SMW 428.50 Purity: 100% Soluble in DMSO Description Strong activator of TMEM16A (ANO1; calcium activated chloride channel;CaCC) without elevating cytoplasmic Ca2+, producing outwardly rectifying currents (EC50 value 3 μM). Eact increases secretion by submucosal glands, as well as by airway surface cells exposed to a proinflammatory milieu; may be useful for treatment of cystic fibrosis (CF), dry mouth, and dry eye syndromes, and motility disorders of the gastrointestinal tract. KEYWORDS:?Eact | supplier | TMEM16A activator | CAS [461000-66-8] | Chloride | ANO1 | calcium activated chloride channel | CaCC | Ion Channel | rectifying current | secretion | cystic fibrosis | CF | dry | motility disorder | gastrointestinal tract

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

Eact

Based on 5 publications in PubMed 9 10 5

Axon 2576

CAS [461000-66-8]

MF C22H24N2O5S
MW 428.50

Purity: 100%
Soluble in DMSO

Eact

Description

Strong activator of TMEM16A (ANO1; calcium activated chloride channel;CaCC) without elevating cytoplasmic Ca2+, producing outwardly rectifying currents (EC50 value 3 μM). Eact increases secretion by submucosal glands, as well as by airway surface cells exposed to a proinflammatory milieu; may be useful for treatment of cystic fibrosis (CF), dry mouth, and dry eye syndromes, and motility disorders of the gastrointestinal tract.

W Namkung et al. Small-molecule activators of TMEM16A, a calcium-activated chloride channel, stimulate epithelial chloride secretion and intestinal contraction. FASEB J. 2011 Nov;25(11):4048-62.

Certificate of Analysis
Material Safety Data Sheet

Cardiovascular CNS Miscellaneous Pain & Inflammation ANO TMEM16A

Activator of TMEM16A (ANO1) without elevating cytoplasmic Ca2+

Chemical name

3,4,5-trimethoxy-N-(2-methoxyethyl)-N-(4-phenylthiazol-2-yl)benzamide

Parent CAS No.

[461000-66-8]

產(chǎn)品資料