產(chǎn)品名稱 EHop 016
產(chǎn)品貨號(hào) Axon 2351 CAS [1380432-32-5] MF C25H30N6OMW 430.55 Purity: 99% Soluble in DMSO Description EHop 016 is a Rac GTPase inhibitor (IC50 value 1.1 μM) specific for Rac1 and Rac3 at concentrations of 5 μM, and inhibits the interaction of Vav2 with Rac1 at physiologically relevant concentrations. Moreover, EHop-016 inhibits the activation of the Rac downstream effector p21-activated kinase (PAK), extension of motile actin-based structures, and cell migration. EHop-016 is ~100 times more potent than NSC 23766 (Axon 1578) and 10–50 times more potent than other currently available Rac inhibitors. References Certificates Categories Extra info B.L. Montalvo-Ortiz et al. Characterization of EHop-016, novel small molecule inhibitor of Rac GTPase. J. Biol. Chem. 2012, 287, 13228-13238. ? S. Dharmawardhane et al.? Development of EHop-016: a small molecule inhibitor of Rac. In Enzymes 2013, 33, 117-146. Ed. F. Tamanoi. ? Certificate of Analysis Material Safety Data Sheet Cell Cycle Regulation Cell Signaling & Oncology Stem Cell EC 3.6.5.2 Rac PAK Rac GTPase inhibitor specific for Rac1 and Rac3 Chemical name N4-(9-ethyl-9H-carbazol-3-yl)-N2-(3-morpholinopropyl)pyrimidine-2,4-diamine Parent CAS No. [1380432-32-5] Order Size Unit Price Stock 10 mg €85.00 In Stock
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EHop 016

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 2351

CAS [1380432-32-5]

MF C25H30N6O
MW 430.55

  • Purity: 99%
  • Soluble in DMSO

EHop 016

Description

EHop 016 is a Rac GTPase inhibitor (IC50 value 1.1 μM) specific for Rac1 and Rac3 at concentrations of 5 μM, and inhibits the interaction of Vav2 with Rac1 at physiologically relevant concentrations. Moreover, EHop-016 inhibits the activation of the Rac downstream effector p21-activated kinase (PAK), extension of motile actin-based structures, and cell migration. EHop-016 is ~100 times more potent than NSC 23766 (Axon 1578) and 10–50 times more potent than other currently available Rac inhibitors.
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