| 產(chǎn)品名稱 | BT2 |
| 產(chǎn)品貨號 | Axon 2334 CAS [34576-94-8] MF C9H4Cl2O2SMW 247.10 Purity: 99% Soluble in DMSO Description Allosteric inhibitor of branched-chain α-ketoacid dehydrogenase (BCKDC) kinase (BDK; IC50 value 3.19 μM). BT 2 binding to BDK results in the dissociation of BDK from the BCKDC accompanied by accelerated degradation of the released kinase in vivo. BT 2 is also known to inhibit the Bcl-2 family member Mcl-1 (Ki value 59 μM). References Certificates Categories Extra info A. Friberg et al. Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design. J. Med. Chem. 2013, 56, 15-30. ? S.C. Tso et al. Benzothiophene carboxylate derivatives as novel allosteric inhibitors of branched-chain α-ketoacid dehydrogenase kinase. J. Biol. Chem. 2014, 289, 20583-20593. Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Cycle Regulation Cell Signaling & Oncology Diabetes & Metabolism BDK Mcl-1 EC 2.7.11.4 Allosteric inhibitor of BCKDC kinase (BDK) and Mcl-1 inhibitor Chemical name 3,6-dichlorobenzo[b]thiophene-2-carboxylic acid Parent CAS No. [34576-94-8] Order Size Unit Price Stock 5 mg €95.00 In Stock |
| 產(chǎn)品價格 | 現(xiàn)貨詢價，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
BT2Axon 2334 CAS [34576-94-8] MF C9H4Cl2O2S
Description
Allosteric inhibitor of branched-chain α-ketoacid dehydrogenase (BCKDC) kinase (BDK; IC50 value 3.19 μM). BT 2 binding to BDK results in the dissociation of BDK from the BCKDC accompanied by accelerated degradation of the released kinase in vivo. BT 2 is also known to inhibit the Bcl-2 family member Mcl-1 (Ki value 59 μM).
Allosteric inhibitor of BCKDC kinase (BDK) and Mcl-1 inhibitor
Chemical name3,6-dichlorobenzo[b]thiophene-2-carboxylic acid Parent CAS No.[34576-94-8] |
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