| 產(chǎn)品名稱 | GW 5074 |
| 產(chǎn)品貨號(hào) | Axon 1984 CAS [220904-83-6] MF #N/AMW #N/A Purity: 99% Soluble in 0.1N NaOH(aq) and DMSO Description Potent, brain-permeable inhibitor of c-Raf (IC50 value 9 nM) when tested in vitro with no effect on the activities of CDK1/2/5/6, JNK1/2/3, c-Src, MEK1, p38 MAP kinase, VEGFR2, and c-fms. In contrast to its effect in vitro, treatment of neurons with GW 5074 causes c-Raf activation (when measured in vitro inthe absence of the drug) and stimulates the Raf-MEK-ERK pathway. GW 5074 protects neurons from death in culture and in an in vivo paradigm of neurodegeneration. KEYWORDS: GW 5074 | supplier | C-Raf inhibitor | GW5074 | CAS [220904-83-6] | MEK | RAF | Inhibitor | Raf-1 | cell-permeable | activation | Raf-MEK-ERK | pathway | CNS | neurodegeneration | neuroprotection |
| 產(chǎn)品價(jià)格 | 現(xiàn)貨詢價(jià)，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
GW 5074Axon 1984 CAS [220904-83-6] MF #N/A
DescriptionPotent, brain-permeable inhibitor of c-Raf (IC50 value 9 nM) when tested in vitro with no effect on the activities of CDK1/2/5/6, JNK1/2/3, c-Src, MEK1, p38 MAP kinase, VEGFR2, and c-fms. In contrast to its effect in vitro, treatment of neurons with GW 5074 causes c-Raf activation (when measured in vitro inthe absence of the drug) and stimulates the Raf-MEK-ERK pathway. GW 5074 protects neurons from death in culture and in an in vivo paradigm of neurodegeneration. KEYWORDS: GW 5074 | supplier | C-Raf inhibitor | GW5074 | CAS [220904-83-6] | MEK | RAF | Inhibitor | Raf-1 | cell-permeable | activation | Raf-MEK-ERK | pathway | CNS | neurodegeneration | neuroprotection
Brain-permeable inhibitor of c-Raf (in vitro) with activating effects in vivo
Chemical name3-(3,5-dibromo-4-hydroxybenzylidene)-5-iodoindolin-2-one Parent CAS No.[220904-83-6] |
| 產(chǎn)品資料 |
