| 產(chǎn)品名稱 | PLX 4032 - RG 7204 | Vemurafenib | RO 5185426 |
| 產(chǎn)品貨號 | Axon 1624 CAS [918504-65-1] MF C23H18ClF2N3O3SMW 489.92 Purity: 98% Soluble in DMSO Description Selective inhibitor of protein kinase, targeting B-Raf (V600E) (IC50: 44 nM); PLX4032 has been shown to cause programmed cell death in melanoma cell lines; a potential anti-tumor agent under clinical trials References Certificates Categories Extra info G Bollag et al. Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma. Nature 2010, 467, 596–599. ? PI Poulikakos et al. RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF. Nature 2010, 464, 427-430. ? E Sala et al. BRAF Silencing by Short Hairpin RNA or Chemical Blockade by PLX4032 Leads to Different Responses in Melanoma and Thyroid Carcinoma Cells. Mol. Cancer Res. 2008, 6(5), 751-759. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology MAPK EC 2.7.11.1 RAF B-Raf protein kinase inhibitor Chemical name N-(3-(5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide Parent CAS No. [918504-65-1] Order Size Unit Price Stock 5 mg €75.00 In Stock |
| 產(chǎn)品價(jià)格 | 現(xiàn)貨詢價(jià)，電話：010-67529703 |
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| 產(chǎn)品品牌 | axonmedchem |
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| 產(chǎn)品詳情 |
PLX 4032 - RG 7204 | Vemurafenib | RO 5185426Axon 1624 CAS [918504-65-1] MF C23H18ClF2N3O3S
Description
Selective inhibitor of protein kinase, targeting B-Raf (V600E) (IC50: 44 nM); PLX4032 has been shown to cause programmed cell death in melanoma cell lines; a potential anti-tumor agent under clinical trials
B-Raf protein kinase inhibitor
Chemical nameN-(3-(5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide Parent CAS No.[918504-65-1] |
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