產(chǎn)品名稱

SB 706504 - PCG

產(chǎn)品貨號(hào)

Axon 2444 CAS [911110-38-8] MF C24H19F3N8OMW 492.46 Purity: 98% Soluble in DMSO Description Selective p38-MAPK inhibitor that targets a subset of inflammatory macrophage genes (IC50 value 2.5 nM for p38α, and no IC50 values ?below 5 μM, except for JNK1 (5 μM)).?When used with dexamethasone, SB 706504 causes effective suppression of these genes without affecting transcription of a subset of LPS-regulated genes, including IL-1β, IL-18, and CCL5 (genes involved in the pathogenesis of COPD).?Furthermore, SB 706504 reduces TNFα, GM-CSF, and IL-6 production from LPS-stimulated COPD macrophages, with less effect on IL-8 production. ?KEYWORDS: SB 706504 | Supplier | p38 MAPK inhibitor | Axon Medchem | Axon 2444 | PCG | SB706504 | CAS [911110-38-8] | MAPK (p38) | Inhibitor | COPD | macrophage | inflammation | LPS | TNFα | cytokines

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

SB 706504 - PCG

Based on 12 reference(s) in Google Scholar 9 10 12

Axon 2444

CAS [911110-38-8]

MF C24H19F3N8O
MW 492.46

Purity: 98%
Soluble in DMSO

SB 706504

Description

Selective p38-MAPK inhibitor that targets a subset of inflammatory macrophage genes (IC50 value 2.5 nM for p38α, and no IC50 values ?below 5 μM, except for JNK1 (5 μM)).?When used with dexamethasone, SB 706504 causes effective suppression of these genes without affecting transcription of a subset of LPS-regulated genes, including IL-1β, IL-18, and CCL5 (genes involved in the pathogenesis of COPD).?Furthermore, SB 706504 reduces TNFα, GM-CSF, and IL-6 production from LPS-stimulated COPD macrophages, with less effect on IL-8 production.

L.M. Kent et al. Inhibition of lipopolysaccharide-stimulated chronic obstructive pulmonary disease macrophage inflammatory gene expression by dexamethasone and the p38 MAPK inhibitor (SB706504). J Pharmacol Exp Ther. 2009 Feb;328(2):458-68.

S.J. Tudhope et al. Different mitogen-activated protein kinase-dependent cytokine responses in cells of the monocyte lineage. J Pharmacol Exp Ther. 2008 Jan;324(1):306-12.

Certificate of Analysis
Material Safety Data Sheet

Cell Signaling & Oncology Pain & Inflammation MAPK (p38) NF-κB MAPK EC 2.7.11.24

Selective p38 MAPK inhibitor that targets a subset of inflammatory macrophage genes.

Chemical name

N-cyano-N'-[2-[[8-(2,6-difluorophenyl)-4-(4-fluoro-2-methylphenyl)-7,8-dihydro-7-oxopyrido[2,3-d]pyrimidin-2-yl]amino]ethyl]-guanidine

Parent CAS No.

[911110-38-8]

產(chǎn)品資料