產(chǎn)品名稱

BPKDi

產(chǎn)品貨號(hào)

Axon 2798 CAS [1201673-28-0] MF C21H28N6OMW 380.49 Purity: 99% Soluble in 0.1N HCl(aq) and DMSO Description BPKDi is an inhibitor of protein kinase D (IC50 values of 1, 9, and 1 nM for PKD1, PKD2 and PKD3, respectively). BPKDi blocks signal-dependent phosphorylation and nuclear export of class IIa HDACs in cardiomyocytes and concomitantly suppresses hypertrophy of these cells. KEYWORDS: BPKDi | supplier | PKD inhibitor | CAS [1201673-28-0] | Non Selective (Phosphorylation Substrates) | PKD | Inhibitor | Enzymes | Cardiac Class IIa HDAC

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

BPKDi

Based on 2 reference(s) in Google Scholar 8 10 2

Axon 2798

CAS [1201673-28-0]

MF C21H28N6O
MW 380.49

Purity: 99%
Soluble in 0.1N HCl(aq) and DMSO

BPKDi

Description

BPKDi is an inhibitor of protein kinase D (IC50 values of 1, 9, and 1 nM for PKD1, PKD2 and PKD3, respectively). BPKDi blocks signal-dependent phosphorylation and nuclear export of class IIa HDACs in cardiomyocytes and concomitantly suppresses hypertrophy of these cells.

L Monovich et al. A novel kinase inhibitor establishes a predominant role for protein kinase D as a cardiac class IIa histone deacetylase kinase. FEBS Lett. 2010 Feb 5;584(3):631-7

EL Meredith et al. Identification of potent and selective amidobipyridyl inhibitors of protein kinase D. J Med Chem. 2010 Aug 12;53(15):5422-38.

Certificate of Analysis
Material Safety Data Sheet

Cardiovascular EC 2.7.11.13 PKD

PKD inhibitor

Chemical name

2'-(Cyclohexylamino)-6-(piperazin-1-yl)-2,4'-bipyridine-4-carboxamide

Parent CAS No.

[1201673-28-0]

產(chǎn)品資料