產(chǎn)品名稱(chēng)

ARM1 hydrobromide

產(chǎn)品貨號(hào)

Axon 2307 CAS [1049743-03-4] MF C16H14N2S.HBrMW 347.27 Purity: 99% Soluble in DMSO Description Novel type of LTA4H inhibitor (IC50 value of ~0.5 μM in human neutrophils, and Ki value of 2.3 μM for purified LTA4H) that selectively blocks the conversion of LTA4 into proinflammatory mediator LTB4, although leaving the aminopeptidase activity intact for cleavage and inactivation of Pro-Gly-Pro.About LTA4H: Leukotriene A4 hydrolase/aminopeptidase (LTA4H) is a bifunctional zinc metalloenzyme that catalyzes biosynthesis of the proinflammatory mediator, LTB4, implicated in chronic inflammatory diseases. Recently, the chemotactic tripeptide Pro-Gly-Pro was identified as the enzyme’s endogenous peptidase substrate. KEYWORDS:?ARM1 hydrobromide | supplier | LTA4H inhibitor | ARM1 HBr | CAS [1049743-03-4] | [68729-05-5] | Eicosanoid epoxides | LTA4H | Inhibitor | neutrophils | LTA4 | proinflammatory mediator | LTB4 | aminopeptidasePro-Gly-Pro | inflammation

產(chǎn)品價(jià)格

現(xiàn)貨詢(xún)價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

ARM1 hydrobromide

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 2307

CAS [1049743-03-4]

MF C16H14N2S.HBr
MW 347.27

Purity: 99%
Soluble in DMSO

ARM1 hydrobromide

Description

Novel type of LTA4H inhibitor (IC50 value of ~0.5 μM in human neutrophils, and Ki value of 2.3 μM for purified LTA4H) that selectively blocks the conversion of LTA4 into proinflammatory mediator LTB4, although leaving the aminopeptidase activity intact for cleavage and inactivation of Pro-Gly-Pro.About LTA4H: Leukotriene A4 hydrolase/aminopeptidase (LTA4H) is a bifunctional zinc metalloenzyme that catalyzes biosynthesis of the proinflammatory mediator, LTB4, implicated in chronic inflammatory diseases. Recently, the chemotactic tripeptide Pro-Gly-Pro was identified as the enzyme’s endogenous peptidase substrate.

A. Stsiapanava et al. Binding of Pro-Gly-Pro at the active site of leukotriene A4 hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor. Proc. Natl. Acad. Sci. USA. 2014, 111, 4227-4232.

Certificate of Analysis
Material Safety Data Sheet

Cell Signaling & Oncology Pain & Inflammation NF-κB LTA4H EC 3.3.2.6

Novel type of LTA4H inhibitor that selectively blocks the conversion of LTA4 into LTB4

Chemical name

4-(4-benzylphenyl)thiazol-2-amine hydrobromide

Parent CAS No.

[68729-05-5]

產(chǎn)品資料