產(chǎn)品名稱(chēng) Cerdulatinib - PRT 062070
產(chǎn)品貨號(hào) Axon 2775 CAS [1198300-79-6] MF C20H27N7O3SMW 445.54 Purity: 98% Soluble in DMSO Description Cerdulatinib is an orally active kinase inhibitor that demonstrates activity against Syk and JAK with IC50 values of 32 nM, 12 nM, 6 nM and 8 nM for Syk, JAK1, JAK2 and JAK3, respectively. Cellular assays demonstrated specific inhibitory activity against signaling pathways that use Syk and JAK1/3. Limited inhibition of JAK2 was observed. Potent antitumor activity was observed in a subset of B-cell lymphoma cell lines. KEYWORDS: Cerdulatinib | support | Syk/JAK inhibitor | PRT 062070 | PRT062070 | PRT-062070 | CAS [1198300-79-6] | CAS [1369761-01-2] | B-Cell Transformation | Spleen tyrosine kinase (Syk) | JAK | Inhibitor | Enzymes | B-cell lymphoma
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Cerdulatinib - PRT 062070

Based on 10 reference(s) in Google Scholar 8 10 10

Axon 2775

CAS [1198300-79-6]

MF C20H27N7O3S
MW 445.54

  • Purity: 98%
  • Soluble in DMSO

Cerdulatinib

Description

Cerdulatinib is an orally active kinase inhibitor that demonstrates activity against Syk and JAK with IC50 values of 32 nM, 12 nM, 6 nM and 8 nM for Syk, JAK1, JAK2 and JAK3, respectively. Cellular assays demonstrated specific inhibitory activity against signaling pathways that use Syk and JAK1/3. Limited inhibition of JAK2 was observed. Potent antitumor activity was observed in a subset of B-cell lymphoma cell lines.

KEYWORDS: Cerdulatinib | support | Syk/JAK inhibitor | PRT 062070 | PRT062070 | PRT-062070 | CAS [1198300-79-6] | CAS [1369761-01-2] | B-Cell Transformation | Spleen tyrosine kinase (Syk) | JAK | Inhibitor | Enzymes | B-cell lymphoma

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