產品名稱 BTB 1 - NSC 156750 | NSC 658180
產品貨號 Axon 2407 CAS [86030-08-2] MF C12H8ClNO4SMW 297.71 Purity: 99% Soluble in DMSO and Ethanol Description The first small molecule reversible inhibitor of the mitotic motor protein Kif18A (IC50 value 1.69 μM for inhibition of Kif18A ATPase activity) that acts in an ATP-competitive and microtubule (Mt) uncompetitive manner. BTB-1 (aka NSC 156750 or NSC 658180) was previously tested and found to inhibit HIV-1 replication (IC50 value 29.2 μM in cellular anti-HIV-1 assay), yet BTB1 proved to be cytotoxic at low micromolar concentrations. References Certificates Categories Extra info J. Braun et al. Synthesis and Biological Evaluation of Optimized Inhibitors of the Mitotic Kinesin Kif18A. ACS Chem Biol. 2015 Feb 20;10(2):554-60. ? M. Catarinella et al. BTB-1: a small molecule inhibitor of the mitotic motor protein Kif18A. Angew Chem Int Ed Engl. 2009;48(48):9072-6. ? N. Neamati et al. Diarylsulfones, a novel class of human immunodeficiency virus type 1 integrase inhibitors. Antimicrob Agents Chemother. 1997 Feb;41(2):385-93. Certificate of Analysis Material Safety Data Sheet Cell Cycle Regulation Cell Signaling & Oncology Kif18A EC 3.6.4.4 The first small molecule reversible inhibitor of the mitotic motor protein Kif18A Chemical name 4-chloro-2-nitro-1-(phenylsulfonyl)benzene Parent CAS No. [86030-08-2] Order Size Unit Price Stock 10 mg €70.00 In Stock
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BTB 1 - NSC 156750 | NSC 658180

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 2407

CAS [86030-08-2]

MF C12H8ClNO4S
MW 297.71

  • Purity: 99%
  • Soluble in DMSO and Ethanol

BTB 1

Description

The first small molecule reversible inhibitor of the mitotic motor protein Kif18A (IC50 value 1.69 μM for inhibition of Kif18A ATPase activity) that acts in an ATP-competitive and microtubule (Mt) uncompetitive manner.

BTB-1 (aka NSC 156750 or NSC 658180) was previously tested and found to inhibit HIV-1 replication (IC50 value 29.2 μM in cellular anti-HIV-1 assay), yet BTB1 proved to be cytotoxic at low micromolar concentrations.
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