產(chǎn)品名稱 KHS101 hydrochloride
產(chǎn)品貨號(hào) Axon 2901 CAS [1784282-12-7] MF C18H21N5S.HClMW 375.92 Purity: 99% Soluble in water and DMSO Description KHS101 hydrochloride is a brain-penetrable TACC3 inhibitor known to enhance neuronal differentiation (EC50 value of 1 μM in cultured rat NPCs) and inhibit cell cycle progression and proliferation. KHS101 hydrochloride works indirectly on HIF complex formation by destabilizing both TACC3 and the HIF component HIF-1α. KHS101 hydrochloride suppresses proliferation, migration, and invasive capabilities of breast cancer cells, EMT process, and mammosphere forming capability, alters cell cycle progression, and induces apoptosis. KEYWORDS: SKHS101 hydrochloride | supplier | TACC3 inhibitor | KHS 101 hydrochloride | KHS-101 hydrochloride | CAS [1784282-12-7] | [1262770-73-9] | Microtubules | TACC | Inhibitor | Proteins | TACC3 | NPC | HIF | HIF-1α | Breast cancer
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KHS101 hydrochloride

Based on 7 reference(s) in Google Scholar 8 10 7

Axon 2901

CAS [1784282-12-7]

MF C18H21N5S.HCl
MW 375.92

  • Purity: 99%
  • Soluble in water and DMSO

KHS101 hydrochloride

Description

KHS101 hydrochloride is a brain-penetrable TACC3 inhibitor known to enhance neuronal differentiation (EC50 value of 1 μM in cultured rat NPCs) and inhibit cell cycle progression and proliferation. KHS101 hydrochloride works indirectly on HIF complex formation by destabilizing both TACC3 and the HIF component HIF-1α. KHS101 hydrochloride suppresses proliferation, migration, and invasive capabilities of breast cancer cells, EMT process, and mammosphere forming capability, alters cell cycle progression, and induces apoptosis.

KEYWORDS: SKHS101 hydrochloride | supplier | TACC3 inhibitor | KHS 101 hydrochloride | KHS-101 hydrochloride | CAS [1784282-12-7] | [1262770-73-9] | Microtubules | TACC | Inhibitor | Proteins | TACC3 | NPC | HIF | HIF-1α | Breast cancer

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