產(chǎn)品名稱 WX-132-18B
產(chǎn)品貨號(hào) Axon 2816 CAS [1415262-07-5] MF C18H16N4O2MW 320.35 Purity: 99% Soluble in DMSO Description WX-132-18B is a microtubule-depolymerizing agent that selectively acts on the colchicine-binding site of tubulin and exerts potent in vitro and in vivo anti-tumor effects. Specifically, WX-132-18B exhibited high in vitro cytotoxic activity (GI50 value of 1.9–3.2 nM), significant potency against tubulin assembly (IC50 value of 0.77 μM), and substantial inhibition of colchicine binding (99% at 5 μM). Moreover, WX-132-18B caused cell arrest in G2/M phase. KEYWORDS: WX-132-18B | Supplier | Microtubule inhibitor | WX132-18B | WX 132-18B | CAS [1415262-07-5] | Cytoskeleton | Tubulin | Inhibitor | Proteins | Colchicine | G2/M phase
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WX-132-18B

Based on 2 reference(s) in Google Scholar 8 10 2

Axon 2816

CAS [1415262-07-5]

MF C18H16N4O2
MW 320.35

  • Purity: 99%
  • Soluble in DMSO

WX-132-18B

Description

WX-132-18B is a microtubule-depolymerizing agent that selectively acts on the colchicine-binding site of tubulin and exerts potent in vitro and in vivo anti-tumor effects. Specifically, WX-132-18B exhibited high in vitro cytotoxic activity (GI50 value of 1.9–3.2 nM), significant potency against tubulin assembly (IC50 value of 0.77 μM), and substantial inhibition of colchicine binding (99% at 5 μM). Moreover, WX-132-18B caused cell arrest in G2/M phase.

KEYWORDS: WX-132-18B | Supplier | Microtubule inhibitor | WX132-18B | WX 132-18B | CAS [1415262-07-5] | Cytoskeleton | Tubulin | Inhibitor | Proteins | Colchicine | G2/M phase

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