產(chǎn)品名稱 Vercirnon - GSK-1605786 | CCX282-B | Traficet-EN
產(chǎn)品貨號(hào) Axon 2685 CAS [698394-73-9] MF C22H21ClN2O4SMW 444.93 Purity: 100% Soluble in DMSO Description Vercirnon is an orally bioavailable selective antagonist of the CCR9 chemokine receptor (IC50 values 5.4 nM and 3.4 nM for CCR9-mediated Ca2+ mobilization and chemotaxis on Molt-4 cells, respectively). Based on studies of the crystal structure, vercirnon binds to the intracellular side of the receptor, exerting allosteric antagonism and preventing G-protein coupling. Vercirnon was developed for treatment of inflammatory bowel disease, including Crohn's disease and celiac disease. KEYWORDS: Vercirnon | supplier | CCR9 antagonist | GSK-1605786 | CCX282-B | Traficet-EN | GSK1605786 | GSK 1605786 | CCX282B | CCX282 B | Traficet EN | CAS [698394-73-9] | ?Chemokine | Chemokine | Antagonist | Receptors | Coeliac disease | Crohn's disease | Coeliac | Crohn
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Vercirnon - GSK-1605786 | CCX282-B | Traficet-EN

Based on 22 reference(s) in Google Scholar 8 10 22

Axon 2685

CAS [698394-73-9]

MF C22H21ClN2O4S
MW 444.93

  • Purity: 100%
  • Soluble in DMSO

Vercirnon

Description

Vercirnon is an orally bioavailable selective antagonist of the CCR9 chemokine receptor (IC50 values 5.4 nM and 3.4 nM for CCR9-mediated Ca2+ mobilization and chemotaxis on Molt-4 cells, respectively). Based on studies of the crystal structure, vercirnon binds to the intracellular side of the receptor, exerting allosteric antagonism and preventing G-protein coupling. Vercirnon was developed for treatment of inflammatory bowel disease, including Crohn's disease and celiac disease.

KEYWORDS: Vercirnon | supplier | CCR9 antagonist | GSK-1605786 | CCX282-B | Traficet-EN | GSK1605786 | GSK 1605786 | CCX282B | CCX282 B | Traficet EN | CAS [698394-73-9] | ?Chemokine | Chemokine | Antagonist | Receptors | Coeliac disease | Crohn's disease | Coeliac | Crohn
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