產(chǎn)品名稱

AMD 3465 hexahydrobromide

產(chǎn)品貨號

Axon 1930 CAS [185991-07-5] MF C24H38N6.6HBrMW 896.07 Purity: 98% Soluble in water and DMSO Description Potent and selective CXCR4 antagonist; Potent anti-HIV agent that specifically blocks the interaction of HIV gp120 with CXCR4. Compared to AMD 3100 (Axon 1738), AMD3465 was even 10-fold more effective as a CXCR4 antagonist, while showing no interaction whatsoever with CCR5; AMD3465 has the potential to mobilize hematopoietic stem cells References Certificates Categories Extra info S Hatse et al. AMD3465, a monomacrocyclic CXCR4 antagonist and potent HIV entry inhibitor. Biochem. Pharmacol. 2005, 70(5), 752-761.? ? MM Rosenkilde et al. Molecular mechanism of action of monocyclam versus bicyclam non-peptide antagonists of the CXCR4 chemokine receptor. J. Biol. Chem. 2007, 282, 27354.? ? V Bodart et al. Pharmacology of AMD3465: a small molecule antagonist of the chemokine receptor CXCR4. Biochem. Pharmacol. 2009, 78(8), 993-1000. ? GJ Bridger et al. Synthesis and structure-activity relationships of azamacrocyclic C-X-C chemokine receptor 4 antagonists: analogues containing a single azamacrocyclic ring are potent inhibitors of (...). J. Med. Chem. 2010, 53(3), 1250-1260.? Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology Immunology A2 Chemokine Potent and selective CXCR4 antagonist Chemical name N-(4-((1,4,8,11-tetraazacyclotetradecan-1-yl)methyl)benzyl)-1-(pyridin-2-yl)methanamine hexahydrobromide Parent CAS No. [185991-24-6] Order Size Unit Price Stock 5 mg €85.00 In Stock

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axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

AMD 3465 hexahydrobromide

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 1930

CAS [185991-07-5]

MF C24H38N6.6HBr
MW 896.07

Purity: 98%
Soluble in water and DMSO

AMD 3465 hexahydrobromide

Description

Potent and selective CXCR4 antagonist; Potent anti-HIV agent that specifically blocks the interaction of HIV gp120 with CXCR4. Compared to AMD 3100 (Axon 1738), AMD3465 was even 10-fold more effective as a CXCR4 antagonist, while showing no interaction whatsoever with CCR5; AMD3465 has the potential to mobilize hematopoietic stem cells

S Hatse et al. AMD3465, a monomacrocyclic CXCR4 antagonist and potent HIV entry inhibitor. Biochem. Pharmacol. 2005, 70(5), 752-761.?

MM Rosenkilde et al. Molecular mechanism of action of monocyclam versus bicyclam non-peptide antagonists of the CXCR4 chemokine receptor. J. Biol. Chem. 2007, 282, 27354.?

V Bodart et al. Pharmacology of AMD3465: a small molecule antagonist of the chemokine receptor CXCR4. Biochem. Pharmacol. 2009, 78(8), 993-1000.

GJ Bridger et al. Synthesis and structure-activity relationships of azamacrocyclic C-X-C chemokine receptor 4 antagonists: analogues containing a single azamacrocyclic ring are potent inhibitors of (...). J. Med. Chem. 2010, 53(3), 1250-1260.?

Certificate of Analysis
Material Safety Data Sheet

Cell Signaling & Oncology Immunology A2 Chemokine

Potent and selective CXCR4 antagonist

Chemical name

N-(4-((1,4,8,11-tetraazacyclotetradecan-1-yl)methyl)benzyl)-1-(pyridin-2-yl)methanamine hexahydrobromide

Parent CAS No.

[185991-24-6]

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