產品名稱

SB 265610

產品貨號

Axon 1559 CAS [ 211096-49-0] MF C14H9BrN6OMW 357.16 Purity: 99% Soluble in DMSO Description Potent allosteric, inverse agonist/antagonist at the human chemokine CXCR2 receptor. SB-265610 antagonizes rat cytokine-induced neutrophil chemoattractant-1 (CINC-1)-induced calcium mobilization, and rat neutrophil chemotaxis in a concentration-dependent manner (IC50 values 3.7 nM and 70 nM, respectively). KEYWORDS:?SB 265610 | supplier | CXCR2 antagonist | SB265610 | CAS [ 211096-49-0] | Chemokine | Inverse agonist | Antagonist | C-X-C | neutrophil | chemotaxis | calcium mobilization | GPCR

產品價格

現(xiàn)貨詢價，電話：010-67529703

產品規(guī)格

產品品牌

axonmedchem

產品概述

產品詳情

SB 265610

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 1559

CAS [ 211096-49-0]

MF C14H9BrN6O
MW 357.16

Purity: 99%
Soluble in DMSO

SB 265610

Description

Potent allosteric, inverse agonist/antagonist at the human chemokine CXCR2 receptor. SB-265610 antagonizes rat cytokine-induced neutrophil chemoattractant-1 (CINC-1)-induced calcium mobilization, and rat neutrophil chemotaxis in a concentration-dependent manner (IC50 values 3.7 nM and 70 nM, respectively).

RL Auten et al. Nonpeptide CXCR2 Antagonist Prevents Neutrophil Accumulation in Hyperoxia-Exposed Newborn Rats. J. Pharmcol. Exp. Ther. 2001, 299(1), 90-95.

V Bhandari and JA Elias. Cytokines in tolerance to hyperoxia-induced injury in the developing and adult lung. Free Rad. Biol. Med. 2006, 41(1), 4-18.

ME Bradley et al. SB265610 is an allosteric, inverse agonist at the human CXCR2 receptor. Br J Pharmacol. 2009 Sep;158(1):328-38.

RL Auten et al. Nonpeptide CXCR2 antagonist prevents neutrophil accumulation in hyperoxia-exposed newborn rats. J Pharmacol Exp Ther. 2001 Oct;299(1):90-5.

Certificate of Analysis
Material Safety Data Sheet

Cell Signaling & Oncology Immunology A2 Chemokine

CXCR2 antagonist

Chemical name

Urea, N-(2-bromophenyl)-N'-(7-cyano-1H-benzotriazol-4-yl)-

Parent CAS No.

[ 211096-49-0]

產品資料