產(chǎn)品名稱 GSK-LSD1
產(chǎn)品貨號 Axon 2375 CAS [N.A.] MF C14H20N2.2HClMW 289.24 Purity: 99% Optical purity: mixture of trans-diastereomers Soluble in water and DMSO Description Irreversible inhibitor of the KDM1 family histone demethylase LSD1 (IC50 value 16 nM). GSK-LSD1 is >1000 fold selective over closely related FAD utilizing enzymes (i.e. LSD2, MAO-A, MAO-B), induces gene expression changes in cancer cell lines (average EC50 <5 nM), and inhibits cancer cell line growth (average EC50 <5 nM). References Certificates Categories Extra info O. Munoz et al. Aryl- and heteroarylcyclopropylamine compounds as LSD1 inhibitors and their preparation. PCT Int. Appl. (2013), WO 2013057320 A1 20130425. ? D.P. Mould et al. Reversible Inhibitors of LSD1 as Therapeutic Agents in Acute Myeloid Leukemia: Clinical Significance and Progress to Date. Med Res Rev. 2014 Nov 24. ? J. McGrath et al. Targeting histone lysine methylation in cancer. Pharmacol Ther. 2015 Jan 9. pii: S0163-7258(15)00003-0. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology Epigenetics Immunology EC 1.14.11 Histone demethylase Irreversible inhibitor of the KDM1 family histone demethylase LSD1 Chemical name rel-N-((1R,2S)-2-phenylcyclopropyl)piperidin-4-amine dihydrochloride Parent CAS No. [1431368-48-7] Order Size Unit Price Stock 10 mg €110.00 In Stock
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GSK-LSD1

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 2375

CAS [N.A.]

MF C14H20N2.2HCl
MW 289.24

  • Purity: 99%
  • Optical purity: mixture of trans-diastereomers
  • Soluble in water and DMSO

GSK-LSD1

Description

Irreversible inhibitor of the KDM1 family histone demethylase LSD1 (IC50 value 16 nM). GSK-LSD1 is >1000 fold selective over closely related FAD utilizing enzymes (i.e. LSD2, MAO-A, MAO-B), induces gene expression changes in cancer cell lines (average EC50 <5 nM), and inhibits cancer cell line growth (average EC50 <5 nM).
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