產(chǎn)品名稱 AZD2716
產(chǎn)品貨號 Axon 2661 CAS [1845753-81-2] MF C24H23NO3MW 373.44 Purity: 99% Optical purity: 98% e.e. Soluble in 0.1N NaOH (aq) and DMSO Description AZD2716 is a novel, potent sPLA2 inhibitor (IC50 values of 10, 40, and 400 nM for sPLA2-IIa, -V, and -X, respectively) with excellent preclinical pharmacokinetic properties across species, clear in vivo efficacy, and minimized safety risk. When incubated with HepG2 cells, AZD2716 effectively inhibited sPLA2 activity (IC50 value of <14 nM) and suppressed production of sPLA2-IIa (IC50 value of 176 nM). AZD2716 also demonstrated significant sPLA2 activity inhibition (IC50 value of 56 nM) in atherosclerotic plaque homogenates.
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產(chǎn)品品牌 axonmedchem
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AZD2716

Based on 2 reference(s) in Google Scholar 8 10 2

Axon 2661

CAS [1845753-81-2]

MF C24H23NO3
MW 373.44

  • Purity: 99%
  • Optical purity: 98% e.e.
  • Soluble in 0.1N NaOH (aq) and DMSO

AZD2716

Description

AZD2716 is a novel, potent sPLA2 inhibitor (IC50 values of 10, 40, and 400 nM for sPLA2-IIa, -V, and -X, respectively) with excellent preclinical pharmacokinetic properties across species, clear in vivo efficacy, and minimized safety risk. When incubated with HepG2 cells, AZD2716 effectively inhibited sPLA2 activity (IC50 value of <14 nM) and suppressed production of sPLA2-IIa (IC50 value of 176 nM). AZD2716 also demonstrated significant sPLA2 activity inhibition (IC50 value of 56 nM) in atherosclerotic plaque homogenates.

KEYWORDS: AZD2716 | supplier | sPLA2 inhibitor | AZD 2716 | AZD-2716 | CAS [1845753-81-2] | Phospholipids | PLA2 | Inhibitor | Enzymes | Coronary Artery Disease
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