產(chǎn)品名稱 CPI 455
產(chǎn)品貨號 Axon 2573 CAS [1628208-23-0] MF C16H14N4OMW 278.31 Purity: 99% Soluble in DMSO Description Selective inhibitor of KDM5 demethylases (IC50 value 10 nM for inhibition of full length KDM5A) that specifically alters H3K4 methylation in several cell contexts and reduces survival of drug-tolerant cancer cells. CPI-455 possesses the target specificity required for an in vitro tool compound for exploring KDM5-dependent disease biology, including drug tolerance. Note: CPI 455 can be used in combination with a less potent control compound, by the authors of the 2016 Nature publication referred to as?CPI 4203?(Axon 2622).? KEYWORDS:?CPI 455 | supplier | KDM5 inhibitor | CPI455 | CAS [1628208-23-0] | Histone demethylase | Inhibitor | H3K4 | KDM5A | lysine | methylation | drug tolerance | cancer | DTP | SET-domain
產(chǎn)品價格 現(xiàn)貨詢價，電話：010-67529703
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產(chǎn)品品牌 axonmedchem
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CPI 455

Based on 11 reference(s) in Google Scholar 10 10 11

Axon 2573

CAS [1628208-23-0]

MF C16H14N4O
MW 278.31

  • Purity: 99%
  • Soluble in DMSO

CPI 455

Description

Selective inhibitor of KDM5 demethylases (IC50 value 10 nM for inhibition of full length KDM5A) that specifically alters H3K4 methylation in several cell contexts and reduces survival of drug-tolerant cancer cells. CPI-455 possesses the target specificity required for an in vitro tool compound for exploring KDM5-dependent disease biology, including drug tolerance.

Note: CPI 455 can be used in combination with a less potent control compound, by the authors of the 2016 Nature publication referred to as?CPI 4203?(Axon 2622).?

KEYWORDS:?CPI 455 | supplier | KDM5 inhibitor | CPI455 | CAS [1628208-23-0] | Histone demethylase | Inhibitor | H3K4 | KDM5A | lysine | methylation | drug tolerance | cancer | DTP | SET-domain
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