產(chǎn)品名稱 CS1
產(chǎn)品貨號 Axon 2391 CAS [1448009-94-6] MF C16H12O3MW 252.26 Purity: 99% Soluble in DMSO Description TOPO IIα inhibitor with broad-spectrum in vitro antitumor effects (IC50 values 4.3 μM, 11.5 μM, and 4.6 μM for inhibition of proliferation of breast cancer MDA-MB-231, human lung cancer A549 and human cervical cancer HeLa cell lines, respectively). CS1 functions as a Topo II poison to stabilize Topo II/DNA complex, which leads to DNA damage, cell cycle arrest at G2/M phase and apoptosis, and is 6–10-fold less cytotoxic against HL7702 and HUVEC cells compared with etoposide. References Certificates Categories Extra info W. Chen et al. Design and synthesis of 2-phenylnaphthalenoids as inhibitors of DNA topoisomeraseIIα and antitumor agents. Eur J Med Chem. 2014 Oct 30;86:782-96. ? Y. Shen et al. CS1 is a novel topoisomerase IIα inhibitor with favorable drug resistance profiles. Biochem Biophys Res Commun. 2014 Oct 24;453(3):302-8. Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Signaling & Oncology Immunology DNA-damage Response EC 5.99.1.3 TOPO TOPO IIα inhibitor with broad-spectrum in vitro antitumor effects Chemical name 4-(6-hydroxynaphthalen-2-yl)benzene-1,2-diol Parent CAS No. [1448009-94-6] Order Size Unit Price Stock 10 mg €135.00 In Stock
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CS1

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 2391

CAS [1448009-94-6]

MF C16H12O3
MW 252.26

  • Purity: 99%
  • Soluble in DMSO

CS1

Description

TOPO IIα inhibitor with broad-spectrum in vitro antitumor effects (IC50 values 4.3 μM, 11.5 μM, and 4.6 μM for inhibition of proliferation of breast cancer MDA-MB-231, human lung cancer A549 and human cervical cancer HeLa cell lines, respectively). CS1 functions as a Topo II poison to stabilize Topo II/DNA complex, which leads to DNA damage, cell cycle arrest at G2/M phase and apoptosis, and is 6–10-fold less cytotoxic against HL7702 and HUVEC cells compared with etoposide.
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