產(chǎn)品名稱

MGL-3196 - VIA-3196

產(chǎn)品貨號(hào)

Axon 2657 CAS [920509-32-6] MF C17H12Cl2N6O4MW 435.22 Purity: 99% Soluble in DMSO Description Oral, liver-targeted, selective thyroid hormone receptor β-agonist (EC50 value 0.21 μM for THR-β) that is being developed for the treatment of dyslipidemia. MGL-3196 is 28-fold selective for THR-β over THR-α in an in vitro functional coactivator recruitment assay. KEYWORDS:?MGL-3196 | supplier | THR-β agonist | VIA-3196 | MGL3196 | VIA3196 | CAS [920509-32-6] | Triiodothyronine | thyroid hormone receptor | THR | NR1A | nuclear receptor | dyslipidemia | HDL | LDL | cholesterol | cardiovascular | diabetes | hypercholesterolemic

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

MGL-3196 - VIA-3196

Based on 30 reference(s) in Google Scholar 10 10 30

Axon 2657

CAS [920509-32-6]

MF C17H12Cl2N6O4
MW 435.22

Purity: 99%
Soluble in DMSO

MGL-3196

Description

Oral, liver-targeted, selective thyroid hormone receptor β-agonist (EC50 value 0.21 μM for THR-β) that is being developed for the treatment of dyslipidemia. MGL-3196 is 28-fold selective for THR-β over THR-α in an in vitro functional coactivator recruitment assay.

KEYWORDS:?MGL-3196 | supplier | THR-β agonist | VIA-3196 | MGL3196 | VIA3196 | CAS [920509-32-6] | Triiodothyronine | thyroid hormone receptor | THR | NR1A | nuclear receptor | dyslipidemia | HDL | LDL | cholesterol | cardiovascular | diabetes | hypercholesterolemic

MJ Kelly et al. Discovery of 2-[3,5-dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196), a Highly Selective THR-β agonist....J Med Chem. 2014 May 22;57(10):3912-23.

R Taub et al. Lipid lowering in healthy volunteers treated with multiple doses of MGL-3196, a liver-targeted thyroid hormone receptor-β agonist. Atherosclerosis. 2013 Oct;230(2):373-80.

Certificate of Analysis
Material Safety Data Sheet

Cardiovascular Diabetes & Metabolism THR NR1A

Oral, liver-targeted, selective thyroid hormone receptor β-agonist

Chemical name

2-(3,5-dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile

Parent CAS No.

[920509-32-6]

產(chǎn)品資料