產(chǎn)品名稱

IMD-0354

產(chǎn)品貨號

Axon 2725 CAS [978-62-1] MF C15H8ClF6NO2MW 383.67 Purity: 99% Soluble in 0.1N NaOH(aq) and DMSO Description The IκB kinase-β (IKKβ or IKK-2) inhibitor IMD-0354 inhibited nuclear translocation of NF-κB induced by TNF-α; this attenuated myocardial reperfusion injury and preserved cardiac function after myocardial infarction. TNF-α-induced production of interleukin-1β and monocyte chemoattractant protein-1 was reduced significantly by IMD-0354. IMD-0354 restrained proliferation of mast cells with c-kit mutations and suppressed the growth of human breast cancer cells by arresting cell cycle at the G0-G1 phase and inducing apoptosis. May effectively prevent restenosis. KEYWORD: IMD-0354 | supplier | IKK-2 inhibitor | IMD0354 | IMD 0354 | CAS [978-62-1] | IκB | IKK | Inhibitor | Enzymes | IκB kinase-β | NF-κB | TNF-α | restenosis | breast cancer

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產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

IMD-0354

Based on 57 reference(s) in Google Scholar 8 10 57

Axon 2725

CAS [978-62-1]

MF C15H8ClF6NO2
MW 383.67

Purity: 99%
Soluble in 0.1N NaOH(aq) and DMSO

IMD-0354

Description

The IκB kinase-β (IKKβ or IKK-2) inhibitor IMD-0354 inhibited nuclear translocation of NF-κB induced by TNF-α; this attenuated myocardial reperfusion injury and preserved cardiac function after myocardial infarction. TNF-α-induced production of interleukin-1β and monocyte chemoattractant protein-1 was reduced significantly by IMD-0354. IMD-0354 restrained proliferation of mast cells with c-kit mutations and suppressed the growth of human breast cancer cells by arresting cell cycle at the G0-G1 phase and inducing apoptosis. May effectively prevent restenosis.

Y Onai et al. Inhibition of IkappaB phosphorylation in cardiomyocytes attenuates myocardial ischemia/reperfusion injury. Cardiovasc Res. 2004 Jul 1;63(1):51-9.

A Tanaka et al. A novel NF-kappaB inhibitor, IMD-0354, suppresses neoplastic proliferation of human mast cells with constitutively activated c-kit receptors. Blood. 2005 Mar 15;105(6):2324-31.

A Tanaka et al. A new IkappaB kinase beta inhibitor prevents human breast cancer progression through negative regulation of cell cycle transition. Cancer Res. 2006 Jan 1;66(1):419-26.

R Hamaya et al. A novel IKK inhibitor prevents progression of restenosis after arterial injury in mice. Int Heart J. 2012;53(2):133-8.

Certificate of Analysis
Material Safety Data Sheet

Apoptosis Cardiovascular Cell Cycle Regulation Cell Signaling & Oncology Immunology Transcription Factors NF-κB EC 2.7.11.10 IKK

IKK-2 inhibitor

Chemical name

N-(3,5-Bis(trifluoromethyl)phenyl)-5-chloro-2-hydroxybenzamide

Parent CAS No.

[978-62-1]

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