產(chǎn)品名稱

DY 268

產(chǎn)品貨號

Axon 2561 CAS [1609564-75-1] MF C30H32N4O5SMW 560.66 Purity: 100% Soluble in DMSO Description Highly potent FXR antagonist with a promising in vitro profile (IC50 values 7.5 nM and 468.5 nM in FXR binding assay and cell-based FXR antagonistic assay, respectively). DY 268 shows no FXR agonistic activity nor cytotoxicity, making it an excellent chemical tool to elucidate the biological function of FXR. KEYWORDS: DY 268 | supplier | FXR antagonist | DY268 | CAS [1609564-75-1] | Chenodeoxycholic acid | FXR | Antagonist | Nuclear | Farnesoid X Receptor | cholesterol | metabolism

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

DY 268

Based on 2 publications in PubMed 9 10 2

Axon 2561

CAS [1609564-75-1]

MF C30H32N4O5S
MW 560.66

Purity: 100%
Soluble in DMSO

DY 268

Description

Highly potent FXR antagonist with a promising in vitro profile (IC50 values 7.5 nM and 468.5 nM in FXR binding assay and cell-based FXR antagonistic assay, respectively). DY 268 shows no FXR agonistic activity nor cytotoxicity, making it an excellent chemical tool to elucidate the biological function of FXR.

DD Yu et al. Identification of trisubstituted-pyrazol carboxamide analogs as novel and potent antagonists of farnesoid X receptor. Bioorg Med Chem. 2014 Jun 1;22(11):2919-38.

Certificate of Analysis
Material Safety Data Sheet

Cell Signaling & Oncology FXR NR1H

Highly potent FXR antagonist with a promising in vitro profile

Chemical name

1-(3-methoxybenzyl)-N-(4-methyl-3-(morpholinosulfonyl)phenyl)-3-p-tolyl-1H-pyrazole-4-carboxamide

Parent CAS No.

[1609564-75-1]

產(chǎn)品資料