| 產品名稱 | OSU 03012 |
| 產品貨號 | Axon 2525 CAS [742112-33-0] MF C26H19F3N4OMW 460.45 Purity: 99% Soluble in DMSO Description ATP-competitive PDK-1 inhibitor (IC50 value 5 μM for both PDK-1/PDPK1) that inhibits the growth of thyroid, prostate and breast cancer xenografts in vivo. A Celecoxib (Axon 1919) derivative that inhibits PAK phosphorylation and cell proliferation with reduced Akt phosphorylation by PDK1, without inhibition of cycloogygenases. Moreover, overexpression of constitutively active forms of PDK-1 and Akt partially protected OSU-03012-induced apoptosis. KEYWORDS: OSU 03012 | supplier | PDK-1 inhibitor | OSU03012 | CAS [742112-33-0] | Phosphatidylinositol | PDPK | PAK | Akt | apoptosis | prostate | breast | thyroid | cancer | proliferation | p70S6 | p21 | PKC |
| 產品價格 | 現(xiàn)貨詢價，電話：010-67529703 |
| 產品規(guī)格 | |
| 產品品牌 | axonmedchem |
| 產品概述 | |
| 產品詳情 |
OSU 03012Axon 2525 CAS [742112-33-0] MF C26H19F3N4O
DescriptionATP-competitive PDK-1 inhibitor (IC50 value 5 μM for both PDK-1/PDPK1) that inhibits the growth of thyroid, prostate and breast cancer xenografts in vivo. A Celecoxib (Axon 1919) derivative that inhibits PAK phosphorylation and cell proliferation with reduced Akt phosphorylation by PDK1, without inhibition of cycloogygenases. Moreover, overexpression of constitutively active forms of PDK-1 and Akt partially protected OSU-03012-induced apoptosis. KEYWORDS: OSU 03012 | supplier | PDK-1 inhibitor | OSU03012 | CAS [742112-33-0] | Phosphatidylinositol | PDPK | PAK | Akt | apoptosis | prostate | breast | thyroid | cancer | proliferation | p70S6 | p21 | PKC
ATP-competitive PDK-1 inhibitor reducing PAK/Akt phosphorylation and cell proliferation
Chemical name2-amino-N-(4-(5-(phenanthren-2-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)phenyl)acetamide Parent CAS No.[742112-33-0] |
| 產品資料 |
