產品名稱

Taselisib - GDC 0032 | RG 7604

產品貨號

Axon 2927 CAS [1282512-48-4] MF C24H28N8O2MW 460.53 Purity: 99% Soluble in DMSO Description Taselisib is a β-sparing PI3K inhibitor with Ki values of 0.29, 0.12 and 0.97 nM for PI3Kα, PI3Kδ and PI3Kγ, respectively. Moreover, Taselisib showed improved unbound drug exposure and effectively suppressed growth of tumors in a mouse xenograft model at low drug dose levels. KEYWORDS: Taselisib | supplier | PI3K inhibitor | GDC 0032 | RG 7604 | GDC0032 | GDC-0032 | RG7604 | RG-7604 | CAS [1282512-48-4] | Phosphatidylinositol | PI3K | Inhibitor | Enzymes | Antitumor

產品價格

現(xiàn)貨詢價，電話：010-67529703

產品規(guī)格

產品品牌

axonmedchem

產品概述

產品詳情

Taselisib - GDC 0032 | RG 7604

Based on 27 reference(s) in Google Scholar 8 10 27

Axon 2927

CAS [1282512-48-4]

MF C24H28N8O2
MW 460.53

Purity: 99%
Soluble in DMSO

Taselisib

Description

Taselisib is a β-sparing PI3K inhibitor with Ki values of 0.29, 0.12 and 0.97 nM for PI3Kα, PI3Kδ and PI3Kγ, respectively. Moreover, Taselisib showed improved unbound drug exposure and effectively suppressed growth of tumors in a mouse xenograft model at low drug dose levels.

KEYWORDS: Taselisib | supplier | PI3K inhibitor | GDC 0032 | RG 7604 | GDC0032 | GDC-0032 | RG7604 | RG-7604 | CAS [1282512-48-4] | Phosphatidylinositol | PI3K | Inhibitor | Enzymes | Antitumor

CO Ndubaku et al. Discovery of 2-{3-[2-(1-isopropyl-3-methyl-1H-1,2-4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl]-1H-pyrazol-1-yl}-2-methylpropanamide (GDC-0032): a β-sparing?phosphoinositide 3-kinase inhibitor with high unbound exposure and robust in vivo antitumor activity. J Med Chem. 2013 Jun 13;56(11):4597-610.

Certificate of Analysis
Material Safety Data Sheet

Cell Signaling & Oncology PI3K PI3K-Akt-mTOR EC 2.7.1.153

PI3K inhibitor (p110 β sparing)

Chemical name

2-(4-(2-(1-Isopropyl-3-methyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)-1H-pyrazol-1-yl)-2-methylpropanamide

Parent CAS No.

[1282512-48-4]

產品資料