產(chǎn)品名稱

ML 355

產(chǎn)品貨號

Axon 2873 CAS [1532593-30-8] MF C21H19N3O4S2MW 441.52 Purity: 98% Soluble in DMSO Description Potent inhibitor of 12-lipoxygenase (12-LOX) (IC50 value of 0.34 μM) which shows excellent selectivity against related enzymes (15-LOX-1, 5-LOX, 15-LOX-2, COX-1/-2). Besides, ML 355 exhibits a favourable in vitro ADME and in vivo PK pro?le with activity in disease relevant cell-based systems, such thrombosis (platelet aggregation and calcium mobilization), and diabetes (12-HETE reducing in β -cells). KEYWORDS: ML 355 | supplier | Lipoxygenase inhibitor | ML355 | ML-355 | CAS [1532593-30-8] | Fatty acid (Arachidonic acid) | LOX | Inhibitor | Enzymes | Thrombosis | Diabetes

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現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

ML 355

Based on 4 reference(s) in Google Scholar 8 10 4

Axon 2873

CAS [1532593-30-8]

MF C21H19N3O4S2
MW 441.52

Purity: 98%
Soluble in DMSO

ML 355

Description

Potent inhibitor of 12-lipoxygenase (12-LOX) (IC50 value of 0.34 μM) which shows excellent selectivity against related enzymes (15-LOX-1, 5-LOX, 15-LOX-2, COX-1/-2). Besides, ML 355 exhibits a favourable in vitro ADME and in vivo PK pro?le with activity in disease relevant cell-based systems, such thrombosis (platelet aggregation and calcium mobilization), and diabetes (12-HETE reducing in β -cells).

D Luci et al. Discovery of ML355, a Potent and Selective Inhibitor of Human 12-Lipoxygenase. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-2013 Apr 12.

DK Luci et al. Synthesis and structure-activity relationship studies of 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives as potent and selective inhibitors of 12-lipoxygenase. J Med Chem. 2014 Jan 23;57(2):495-506.

Certificate of Analysis
Material Safety Data Sheet

Cardiovascular Cell Signaling & Oncology Diabetes & Metabolism Pain & Inflammation LOX EC 1.13.11.31

Potent and selective inhibitor of 12-lipoxygenase (LOX)

Chemical name

N-(Benzo[d]thiazol-2-yl)-4-(2-hydroxy-3-methoxybenzylamino)benzenesulfonamide

Parent CAS No.

[1532593-30-8]

產(chǎn)品資料