| 產(chǎn)品名稱 | Begacestat - GSI 953 |
| 產(chǎn)品貨號 | Axon 2117 CAS [769169-27-9] MF C9H8ClF6NO3S2MW 391.74 Purity: 99% Optical purity: Optically pure Soluble in DMSO Description Potent and selective γ-secretase inhibitor (γ-secratase inhibitor, GSI); Capable of reducing both Aβ40 and Aβ42 production in a cell line stably expressing human recombinant APP (EC50 values of 14.8 and 12.4 nM for Aβ40 and Aβ40 respectively). Begacestat was found to have >16-fold selectivity in vitro for the inhibition of APP processing over Notch References Certificates Categories Extra info RL Martone et al. Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease. J. Pharmacol. Exp. Ther. 2009, 331(2), 598-608.? ? SC Mayer et al. Discovery of Begacestat, a Notch-1-Sparing γ-Secretase Inhibitor for the Treatment of Alzheimer’s Disease. J. Med. Chem. 2008, 51(23), 7348-7351.? Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology CNS Stem Cell γ Secretase EC 3.4.23.46 Pfizer Licensed Products Selective γ-secretase inhibitor (GSI) Chemical name (S)-5-chloro-N-(4,4,4-trifluoro-1-hydroxy-3-(trifluoromethyl)butan-2-yl)thiophene-2-sulfonamide Source information Pfizer compound; Sold for research purposes under agreement from Pfizer Inc. Parent CAS No. [769169-27-9] Order Size Unit Price Stock 5 mg €85.00 In Stock |
| 產(chǎn)品價格 | 現(xiàn)貨詢價，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
Begacestat - GSI 953Axon 2117 CAS [769169-27-9] MF C9H8ClF6NO3S2
Description
Potent and selective γ-secretase inhibitor (γ-secratase inhibitor, GSI); Capable of reducing both Aβ40 and Aβ42 production in a cell line stably expressing human recombinant APP (EC50 values of 14.8 and 12.4 nM for Aβ40 and Aβ40 respectively). Begacestat was found to have >16-fold selectivity in vitro for the inhibition of APP processing over Notch
Selective γ-secretase inhibitor (GSI)
Chemical name(S)-5-chloro-N-(4,4,4-trifluoro-1-hydroxy-3-(trifluoromethyl)butan-2-yl)thiophene-2-sulfonamide Source informationPfizer compound; Sold for research purposes under agreement from Pfizer Inc.Parent CAS No.[769169-27-9] |
| 產(chǎn)品資料 |
