產(chǎn)品名稱

BZ, γ-Secretase Inhibitor - Compound E

產(chǎn)品貨號(hào)

Axon 1487 CAS [209986-17-4] MF C27H24F2N4O3MW 490.50 Purity: 99% Optical purity: Optically pure Soluble in DMSO Description Very potent and cell-permeable inhibitor of γ-secretase (GSI); potently inhibits Notch processing (IC50 values to be 2.2 nM in SupT1 cells); inhibits β-ammyloid production in cell culture with an IC50 of 0.3 nM. KEYWORDS: γ-Secretase Inhibitor BZ | supplier | γ-Secretase inhibitor | Compound E | CAS [209986-17-4] | Amyloids | γ Secretase | γ-Secretase inhibitor (GSI) | Inhibitor | Enzymes

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現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

BZ, γ-Secretase Inhibitor - Compound E

Based on 16 reference(s) in Google Scholar 9 10 16

Axon 1487

CAS [209986-17-4]

MF C27H24F2N4O3
MW 490.50

Purity: 99%
Optical purity: Optically pure
Soluble in DMSO

BZ, γ-Secretase Inhibitor

Description

Very potent and cell-permeable inhibitor of γ-secretase (GSI); potently inhibits Notch processing (IC50 values to be 2.2 nM in SupT1 cells); inhibits β-ammyloid production in cell culture with an IC50 of 0.3 nM.

D Seiffert et al. Presenilin-1 and -2 Are Molecular Targets for γ-Secretase Inhibitors. J. Biol. Chem. 2000, 275, 34086-34091.

J Milano et al. Modulation of Notch Processing by?γ-Secretase Inhibitors Causes Intestinal Goblet Cell Metaplasia and Induction of Genes Known to Specify Gut Secretory Lineage Differentiation. Toxicol. Sci. 2004, 82(1), 341-358.?

T Aleksic and SM Feller. Gamma-secretase inhibition combined with platinum compounds enhances cell death in a large subset of colorectal cancer cells. Cell Communication and Signaling 2008, 6, 8.?

Certificate of Analysis
Material Safety Data Sheet

Cell Signaling & Oncology CNS Stem Cell γ Secretase EC 3.4.23.46

γ-Secretase inhibitor (GSI)

Chemical name

(S)-2-[2-(3,5-Difluoro-phenyl)-acetylamino]-N-(1-methyl-2-oxo-5-phenyl-2,3-dihydro-1H-benzo[e][1,4]diazepin-3-yl)-propionamide

Parent CAS No.

[209986-17-4]

產(chǎn)品資料