產(chǎn)品名稱 Isoquinolinediol, 1,5- - NSC 65585
產(chǎn)品貨號(hào) Axon 2537 CAS [5154-02-9] MF C9H7NO2MW 161.16 Purity: 100% Soluble in 0.1N NaOH(aq) and DMSO Description PARP1-specific inhibitor (IC50 value 0.39 - 1.00 μM) and neuroprotective agent, that leads to an increase up to 8-fold in the absolute frequency of gene targeting in the correction of the mutation at the stable integrated HSV tk gene in mouse Ltk cells. Treatment of 1,5-Isoquinolinediol significantly blocked mitochondrial membrane potential loss and AIF (apoptosis inducing factor) and cytochrome c release from the mitochondria. 1,5-Isoquinolinediol did not suppress pristimerin-induced JNK activation. KEYWORDS: 1,5-Isoquinolinediol | supplier | PARP inhibitor |NSC65585 |NSC65585 | CAS [5154-02-9] |DNA-RNA | PARP1 | Inhibitor | DHIQ | DIQ | poly |ADP-ribose | SSB | single strand breaks | Ltk cells | mitochondrial membrane potential |AIF| apoptosis inducing factor | neuroprotetcive | JNK
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Isoquinolinediol, 1,5- - NSC 65585

Based on 240 reference(s) in Google Scholar 9 10 240

Axon 2537

CAS [5154-02-9]

MF C9H7NO2
MW 161.16

  • Purity: 100%
  • Soluble in 0.1N NaOH(aq) and DMSO

Isoquinolinediol, 1,5-

Description

PARP1-specific inhibitor (IC50 value 0.39 - 1.00 μM) and neuroprotective agent, that leads to an increase up to 8-fold in the absolute frequency of gene targeting in the correction of the mutation at the stable integrated HSV tk gene in mouse Ltk cells. Treatment of 1,5-Isoquinolinediol significantly blocked mitochondrial membrane potential loss and AIF (apoptosis inducing factor) and cytochrome c release from the mitochondria. 1,5-Isoquinolinediol did not suppress pristimerin-induced JNK activation.

KEYWORDS: 1,5-Isoquinolinediol | supplier | PARP inhibitor |NSC65585 |NSC65585 | CAS [5154-02-9] |DNA-RNA | PARP1 | Inhibitor | DHIQ | DIQ | poly |ADP-ribose | SSB | single strand breaks | Ltk cells | mitochondrial membrane potential |AIF| apoptosis inducing factor | neuroprotetcive | JNK
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