產(chǎn)品名稱 SMI 481 - 6748-481
產(chǎn)品貨號(hào) Axon 2387 CAS [432020-20-7] MF C17H15ClFN3O3MW 363.77 Purity: 99% Soluble in DMSO Description Small-molecule inhibitor (SMI) of the yeast PITP Sec14 (IC50 values of 211 nM and 2.87 μM for Sec14 mediated [3H]PtdIns transfer in vitro, and Sec14 dependent cell growth inhibition of WT (CTY182, gray) strains, respectively). SMI481 (aka 6748-481 ) is a water-soluble bioactive compound exhibiting exquisite pathway selectivity in inhibiting phosphoinositide signaling in cells with >200-fold selectivity over other yeast Sec14-like transfer activities. PITP-?directed SMIs offer new and generally applicable avenues for intervening with phosphoinositide signaling pathways with selectivities superior to those afforded by contemporary lipid kinase-?directed strategies. References Certificates Categories Extra info A.H. Nile et al. PITPs as targets for selectively interfering with phosphoinositide signaling in cells. Nat Chem Biol. 2014 Jan;10(1):76-84. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology CNS Sec14 First small-molecule inhibitor (SMI) of the yeast PITP Sec14 Chemical name (4-chloro-3-nitrophenyl)(4-(2-fluorophenyl)piperazin-1-yl)methanone Parent CAS No. [432020-20-7] Order Size Unit Price Stock 10 mg €80.00 In Stock
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SMI 481 - 6748-481

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 2387

CAS [432020-20-7]

MF C17H15ClFN3O3
MW 363.77

  • Purity: 99%
  • Soluble in DMSO

SMI 481

Description

Small-molecule inhibitor (SMI) of the yeast PITP Sec14 (IC50 values of 211 nM and 2.87 μM for Sec14 mediated [3H]PtdIns transfer in vitro, and Sec14 dependent cell growth inhibition of WT (CTY182, gray) strains, respectively). SMI481 (aka 6748-481 ) is a water-soluble bioactive compound exhibiting exquisite pathway selectivity in inhibiting phosphoinositide signaling in cells with >200-fold selectivity over other yeast Sec14-like transfer activities. PITP-?directed SMIs offer new and generally applicable avenues for intervening with phosphoinositide signaling pathways with selectivities superior to those afforded by contemporary lipid kinase-?directed strategies.
First small-molecule inhibitor (SMI) of the yeast PITP Sec14

Chemical name

(4-chloro-3-nitrophenyl)(4-(2-fluorophenyl)piperazin-1-yl)methanone

Parent CAS No.

[432020-20-7]
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