產(chǎn)品名稱 AZD 2461
產(chǎn)品貨號(hào) Axon 2241 CAS [1174043-16-3] MF C22H22FN3O3MW 395.43 Purity: 99% Soluble in DMSO Description PARP inhibitor (IC50 value 5 nM) with poor P-glycoprotein substrate qualities. Unlike treatment with AZD 2281 (Olaparib, Axon 1464), AZD 2461 succesfully circumvents drug resistance of Pgp-proficient tumors, and inactivation of p53-binding protein 1 (53BP1) as a causal factor in PARPi resistance. KEYWORDS:?AZD 2461 | supplier | PARP inhibitor | AZD2461 | AZD-2461 | CAS [1174043-16-3] | DNA-RNA | PARP1 | P-gp | AZD 2281 | Olaparib | drug resistance | tumors | p53 | binding protein 1 | 53BP1 | PARPi | resistance
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AZD 2461

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 2241

CAS [1174043-16-3]

MF C22H22FN3O3
MW 395.43

  • Purity: 99%
  • Soluble in DMSO

AZD 2461

Description

PARP inhibitor (IC50 value 5 nM) with poor P-glycoprotein substrate qualities. Unlike treatment with AZD 2281 (Olaparib, Axon 1464), AZD 2461 succesfully circumvents drug resistance of Pgp-proficient tumors, and inactivation of p53-binding protein 1 (53BP1) as a causal factor in PARPi resistance.

KEYWORDS:?AZD 2461 | supplier | PARP inhibitor | AZD2461 | AZD-2461 | CAS [1174043-16-3] | DNA-RNA | PARP1 | P-gp | AZD 2281 | Olaparib | drug resistance | tumors | p53 | binding protein 1 | 53BP1 | PARPi | resistance
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