產品名稱 TPI-1
產品貨號 Axon 2723 CAS [79756-69-7] MF C12H6Cl2O2MW 253.08 Purity: 99% Soluble in DMSO Description SHP1 inhibitor TPI-1 (IC50 value 40 nM) selectively increased SHP1 phospho-substrates (pLck-pY394, pZap70 and pSlp76) in Jurkat T cells but had little effects on pERK1/2 or pLck-pY505 regulated by phosphatases SHP2 or CD45, respectively. TPI-1 was shown to be more effective than sodium stibogluconate in SHP1 inhibition, immune cell activation and anti-tumor action. KEYWORDS: TPI-1 | supplier | SHP1 inhibitor | TPI1 | TPI 1 | CAS [ 79756-69-7 ] | Non Selective (Tyrosine Specific Phosphomonoesters) | SHP | Inhibitor | Enzymes | SHP-1 | tyrosine phosphatase inhibitor-1 | cancer | anti-tumor
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TPI-1

Based on 3 reference(s) in Google Scholar 8 10 3

Axon 2723

CAS [79756-69-7]

MF C12H6Cl2O2
MW 253.08

  • Purity: 99%
  • Soluble in DMSO

TPI-1

Description

SHP1 inhibitor TPI-1 (IC50 value 40 nM) selectively increased SHP1 phospho-substrates (pLck-pY394, pZap70 and pSlp76) in Jurkat T cells but had little effects on pERK1/2 or pLck-pY505 regulated by phosphatases SHP2 or CD45, respectively. TPI-1 was shown to be more effective than sodium stibogluconate in SHP1 inhibition, immune cell activation and anti-tumor action.

KEYWORDS: TPI-1 | supplier | SHP1 inhibitor | TPI1 | TPI 1 | CAS [ 79756-69-7 ] | Non Selective (Tyrosine Specific Phosphomonoesters) | SHP | Inhibitor | Enzymes | SHP-1 | tyrosine phosphatase inhibitor-1 | cancer | anti-tumor
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