產(chǎn)品名稱 NHI 2
產(chǎn)品貨號 Axon 2450 CAS [1269802-97-2] MF C17H12F3NO3MW 335.28 Purity: 99% Soluble in DMSO Description Selective cell membrane permeable inhibitor of human lactate dehydrogenase isoform A (LDH-A; IC50 values 14.7 μM and 55.8 μM in a NADH competition assay for LDH-A and LDH-B, respectively). NHI-2 caused 87% LDH-A inhibition at 125 μM (with minimal activity (11%) on LDH-B at the same concentration), exhibiting anti-proliferative activity in cancer cells. NHI 2 synergistically enhanced the activity of Gemcitabine in multiple cancer cell lines. KEYWORDS: NHI2 | supplier | LDH-A inhibitor | CAS [1269802-97-2] | Lactate | LDH | Inhibitor | pyruvate | glycolysis | dehydrogenase | anti-proliferative | cancer | cytotoxic | hypoxia | cell-cycle | apoptosis | NADH
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產(chǎn)品品牌 axonmedchem
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NHI 2

Based on 24 publications in PubMed 9 10 24

Axon 2450

CAS [1269802-97-2]

MF C17H12F3NO3
MW 335.28

  • Purity: 99%
  • Soluble in DMSO

NHI 2

Description

Selective cell membrane permeable inhibitor of human lactate dehydrogenase isoform A (LDH-A; IC50 values 14.7 μM and 55.8 μM in a NADH competition assay for LDH-A and LDH-B, respectively). NHI-2 caused 87% LDH-A inhibition at 125 μM (with minimal activity (11%) on LDH-B at the same concentration), exhibiting anti-proliferative activity in cancer cells. NHI 2 synergistically enhanced the activity of Gemcitabine in multiple cancer cell lines.

KEYWORDS: NHI2 | supplier | LDH-A inhibitor | CAS [1269802-97-2] | Lactate | LDH | Inhibitor | pyruvate | glycolysis | dehydrogenase | anti-proliferative | cancer | cytotoxic | hypoxia | cell-cycle | apoptosis | NADH
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