產(chǎn)品名稱 PFK 158
產(chǎn)品貨號(hào) Axon 2542 CAS [1462249-75-7] MF C18H11F3N2OMW 328.29 Purity: 99% Soluble in DMSO Description Nanomolar small molecule inhibitor of PFKFB3 (IC50 value 137 nM) that is selectively cytotoxic to cancer cells and displays broad anti-tumor activity causing significant growth inhibition in preclinical models of breast, lung, glioblastoma, ovarian, pancreatic, melanoma and colon cancer. PFK158 is well tolerated in rats and dogs resulting in an acceptable pre-clinical therapeutic index. KEYWORDS: PFK 158 | supplier | PFKFB3 inhibitor | PFK158 | CAS [1462249-75-7] | Fructose 6-phosphate | PFKFB3 | Inhibitor | glycolysis | solid malignancy | Ras | AKT | PI3K | p53 | PTEN | cytotoxic | cancer cells | anti-tumor activity | breast cancer | lung cancer | glioblastoma | ovarian cancer | pancreatic cancer | melanoma | colon cancer
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產(chǎn)品品牌 axonmedchem
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PFK 158

Based on 49 reference(s) in Google Scholar 9 10 49

Axon 2542

CAS [1462249-75-7]

MF C18H11F3N2O
MW 328.29

  • Purity: 99%
  • Soluble in DMSO

PFK 158

Description

Nanomolar small molecule inhibitor of PFKFB3 (IC50 value 137 nM) that is selectively cytotoxic to cancer cells and displays broad anti-tumor activity causing significant growth inhibition in preclinical models of breast, lung, glioblastoma, ovarian, pancreatic, melanoma and colon cancer. PFK158 is well tolerated in rats and dogs resulting in an acceptable pre-clinical therapeutic index.

KEYWORDS: PFK 158 | supplier | PFKFB3 inhibitor | PFK158 | CAS [1462249-75-7] | Fructose 6-phosphate | PFKFB3 | Inhibitor | glycolysis | solid malignancy | Ras | AKT | PI3K | p53 | PTEN | cytotoxic | cancer cells | anti-tumor activity | breast cancer | lung cancer | glioblastoma | ovarian cancer | pancreatic cancer | melanoma | colon cancer
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