| 產(chǎn)品名稱 | AG-221 - Enasidenib |
| 產(chǎn)品貨號(hào) | Axon 2745 CAS [1446502-11-9] MF C19H17F6N7OMW 473.37 Purity: 99% Soluble in DMSO Description AG-221 (Enasidenib) is an oral, selective, first-in-class inhibitor of the mutant IDH2 enzyme (IC50 value of 100 nM). AG-221 demonstrates excellent pharmaceutical properties, including adequate solubility, low clearance, and good oral bioavailability, and potently inhibits 2HG production by both the IDH2R140Q/WT heterodimer and IDH2R140Q homodimer. AG-221 suppressed 2HG production and induced cellular differentiation in primary human IDH2 mutation–positive acute myeloid leukaemia (AML) cells ex vivo and in xenograft mouse models. KEYWORDS: AG-221 | supplier | IDH2 inhibitor |?Enasidenib | AG 221 | AG221 | CAS [1446502-11-9] | Isocitrate | IDH | Inhibitor | Enzymes |
| 產(chǎn)品價(jià)格 | 現(xiàn)貨詢價(jià)，電話：010-67529703 |
| 產(chǎn)品規(guī)格 | |
| 產(chǎn)品品牌 | axonmedchem |
| 產(chǎn)品概述 | |
| 產(chǎn)品詳情 |
AG-221 - EnasidenibAxon 2745 CAS [1446502-11-9] MF C19H17F6N7O
DescriptionAG-221 (Enasidenib) is an oral, selective, first-in-class inhibitor of the mutant IDH2 enzyme (IC50 value of 100 nM). AG-221 demonstrates excellent pharmaceutical properties, including adequate solubility, low clearance, and good oral bioavailability, and potently inhibits 2HG production by both the IDH2R140Q/WT heterodimer and IDH2R140Q homodimer. AG-221 suppressed 2HG production and induced cellular differentiation in primary human IDH2 mutation–positive acute myeloid leukaemia (AML) cells ex vivo and in xenograft mouse models. KEYWORDS: AG-221 | supplier | IDH2 inhibitor |?Enasidenib | AG 221 | AG221 | CAS [1446502-11-9] | Isocitrate | IDH | Inhibitor | Enzymes
IDH2 mutant enzyme inhibitor
Chemical name2-Methyl-1-(4-(6-(trifluoromethyl)pyridin-2-yl)-6-(2-(trifluoromethyl)pyridin-4-ylamino)-1,3,5-triazin-2-ylamino)propan-2-ol Parent CAS No.[1446502-11-9] |
| 產(chǎn)品資料 |
