產(chǎn)品名稱

APPA

產(chǎn)品貨號

Axon 2883 CAS [100750-39-8] MF C14H13NO3MW 243.26 Purity: 99% Soluble in DMSO Recently added

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

APPA

Based on 1 reference(s) in Google Scholar 8 10 1

Axon 2883

CAS [100750-39-8]

MF C14H13NO3
MW 243.26

Purity: 99%
Soluble in DMSO

Recently added

APPA

Description

APPA is an aldose reductase inhibitor with an IC50 value of 0.0223 μM. APPA could inhibit apoptosis in rat glomerular mesangial cells in vitro. In addition, APPA improved the pathological symptoms of streptozotocin-induced diabetic nephropathy (DN) in rats by affecting antioxidant activities and reducing the levels of TGF-β, collagen IV, and laminin.

ZM Xiu et al. 1-Acetyl-5-phenyl-1H-pyrrol-3-ylacetate: An aldose reductase inhibitor for the treatment of diabetic nephropathy. Bioorg Med Chem Lett. 2017 Sep 15;27(18):4482-4487.

Certificate of Analysis
Material Safety Data Sheet

Apoptosis Diabetes & Metabolism Aldose reductase EC 1.1.1.21

Aldose reductase inhibitor

Chemical name

1-Acetyl-5-phenyl-1H-pyrrol-3-yl acetate

Parent CAS No.

[100750-39-8]

產(chǎn)品資料