產(chǎn)品名稱 Niraparib - MK 4827
產(chǎn)品貨號(hào) Axon 2928 CAS [1038915-60-4] MF C19H20N4OMW 320.39 Purity: 100% Optical purity: Optically pure Soluble in DMSO Description Niraparib is a potent, selective and orally available PARP 1/2 inhibitor with IC50 values of 3.8 and 2.1 nM, respectively. Moreover, in a whole cell assay, Niraparib inhibited PARP activity with an EC50 value of 4 nM and inhibited proliferation of cancer cells with mutant BRCA-1 and BRCA-2 (CC50 value of 10?100 nM). Niraparib was well tolerated in vivo and demonstrated efficacy as a single agent in a xenograft model of BRCA-1 deficient cancer. KEYWORDS: Niraparib | supplier | PARP inhibitor | MK 4827 | MK4827 | MK-4827 | CAS [1038915-60-4] | CAS [1038915-64-8] | CAS [1038915-73-9] | DNA-RNA | PARP | Inhibitor | Enzymes | BRCA
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Niraparib - MK 4827

Based on 114 reference(s) in Google Scholar 8 10 114

Axon 2928

CAS [1038915-60-4]

MF C19H20N4O
MW 320.39

  • Purity: 100%
  • Optical purity: Optically pure
  • Soluble in DMSO

Niraparib

Description

Niraparib is a potent, selective and orally available PARP 1/2 inhibitor with IC50 values of 3.8 and 2.1 nM, respectively. Moreover, in a whole cell assay, Niraparib inhibited PARP activity with an EC50 value of 4 nM and inhibited proliferation of cancer cells with mutant BRCA-1 and BRCA-2 (CC50 value of 10?100 nM). Niraparib was well tolerated in vivo and demonstrated efficacy as a single agent in a xenograft model of BRCA-1 deficient cancer.

KEYWORDS: Niraparib | supplier | PARP inhibitor | MK 4827 | MK4827 | MK-4827 | CAS [1038915-60-4] | CAS [1038915-64-8] | CAS [1038915-73-9] | DNA-RNA | PARP | Inhibitor | Enzymes | BRCA

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