產(chǎn)品名稱

MJN110

產(chǎn)品貨號(hào)

Axon 2580 CAS [1438416-21-7] MF C22H21Cl2N3O4MW 462.33 Purity: 98% Soluble in DMSO Description Potent, selective, and in-vivo-active MAGL inhibitor (IC50 values 9.5 nM and 260 nM for inhibition of mouse MAGL and ABHD6, respectively) displaying strong antihyperalgesic activity (mechanical allodynia) in a rat model of diabetic neuropathy. MJN110 exhibits therapeutic potential in the treatment of acute nausea and vomiting as well as anticipatory nausea by elevation of endogenous cannabinoid 2-arachidonoylglycerol (2-AG) levels in the brain. KEYWORDS: MJN110 | supplier | MAGL inhibitor ?| MJN-110 | CAS [1438416-21-7] | 2-arachidonoyl glycerol | 2-AG | MAGL | Inhibitor | endo-cannabinoid | ABHD6 | antihyperalgesic | allodynia | diabetic neuropathy | nausea | vomiting

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

MJN110

Based on 56 reference(s) in Google Scholar 9 10 56

Axon 2580

CAS [1438416-21-7]

MF C22H21Cl2N3O4
MW 462.33

Purity: 98%
Soluble in DMSO

MJN110

Description

Potent, selective, and in-vivo-active MAGL inhibitor (IC50 values 9.5 nM and 260 nM for inhibition of mouse MAGL and ABHD6, respectively) displaying strong antihyperalgesic activity (mechanical allodynia) in a rat model of diabetic neuropathy. MJN110 exhibits therapeutic potential in the treatment of acute nausea and vomiting as well as anticipatory nausea by elevation of endogenous cannabinoid 2-arachidonoylglycerol (2-AG) levels in the brain.

B Ignatowska-Jankowska et al. Selective monoacylglycerol lipase inhibitors: antinociceptive versus cannabimimetic effects in mice. J Pharmacol Exp Ther. 2015 May;353(2):424-32.

MJ Niphakis et al. Evaluation of NHS carbamates as a potent and selective class of endocannabinoid hydrolase inhibitors. ACS Chem Neurosci. 2013 Sep 18;4(9):1322-32.

LA Parker et al. Effect of selective inhibition of monoacylglycerol lipase (MAGL) on acute nausea, anticipatory nausea, and vomiting in rats and Suncus murinus. Psychopharmacology (Berl). 2015 Feb;232(3):583-93.

JW Chang et al. Proteome-wide reactivity profiling identifies diverse carbamate chemotypes tuned for serine hydrolase inhibition. ACS Chem Biol. 2013 Jul 19;8(7):1590-9.

Certificate of Analysis
Material Safety Data Sheet

Cell Signaling & Oncology CNS Diabetes & Metabolism Pain & Inflammation MAGL EC 3.1.1.23

Potent, selective, and in-vivo-active MAGL inhibitor

Chemical name

2,5-dioxopyrrolidin-1-yl 4-(bis(4-chlorophenyl)methyl)piperazine-1-carboxylate

Parent CAS No.

[1438416-21-7]

產(chǎn)品資料