產(chǎn)品名稱

IWR-1-endo - IWR-1 | endo-IWR-1

產(chǎn)品貨號(hào)

Axon 2510 CAS [1127442-82-3] MF C25H19N3O3MW 409.44 Purity: 99% Soluble in DMSO Description Small-molecule inhibitor of the Wnt/β-catenin pathway (IC50 value 0.18 μM), strongly inhibiting TNKS1 and TNKS2 in biochemical assays, and targeting the acyltransferase Porcupine (Porcn) without inducing Porcn destruction or mislocalization. IWR-1-endo significantly stabilized endogenous TNKS1, TNKS2 and axin?2 by inhibition of auto-PARsylation of TNKS in vivo and independent of the PARsylation activity of PARP1/2. Furthermore, IWR-1 increased expression of genes commonly expressed in cardiac mesoderm/progenitor cell and significantly improved cardiac differentiation when introduced after the application of BMP-4. KEYWORDS: IWR-1-endo | Supplier | Wnt/TNKS inhibitor | IWR-1 | IWR1 | CAS [1127442-82-3] | DNA-RNA | TNKS1 | TNKS2 | Tankyrase | Inhibitor | catenin | parp | parsylation | axin | cardiac | differentiation | Porcupine | Porcn

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

IWR-1-endo - IWR-1 | endo-IWR-1

Based on 15 reference(s) in Google Scholar 8 10 15

Axon 2510

CAS [1127442-82-3]

MF C25H19N3O3
MW 409.44

Purity: 99%
Soluble in DMSO

IWR-1-endo

Description

Small-molecule inhibitor of the Wnt/β-catenin pathway (IC50 value 0.18 μM), strongly inhibiting TNKS1 and TNKS2 in biochemical assays, and targeting the acyltransferase Porcupine (Porcn) without inducing Porcn destruction or mislocalization. IWR-1-endo significantly stabilized endogenous TNKS1, TNKS2 and axin?2 by inhibition of auto-PARsylation of TNKS in vivo and independent of the PARsylation activity of PARP1/2. Furthermore, IWR-1 increased expression of genes commonly expressed in cardiac mesoderm/progenitor cell and significantly improved cardiac differentiation when introduced after the application of BMP-4.

S.M. Huang et al. Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling. Nature. 2009 Oct 1;461(7264):614-20.

B. Chen et al. Small molecule-mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer. Nat Chem Biol. 2009 Feb;5(2):100-7.

C. Liu et al. Destruction of a destructor: a new avenue for cancer therapeutics targeting the Wnt pathway. J Mol Cell Biol. 2010 Apr;2(2):70-3.

Y. Ren et al. Small molecule Wnt inhibitors enhance the efficiency of BMP-4-directed cardiac differentiation of human pluripotent stem cells. J Mol Cell Cardiol. 2011 Sep;51(3):280-7.

Certificate of Analysis
Material Safety Data Sheet

Cardiovascular Cell Cycle Regulation Cell Signaling & Oncology Stem Cell Porcupine Wnt-β-Catenin DNA-damage Response EC 2.4.2.30 TNKS

Inhibitor of the Wnt/β-catenin pathway strongly inhibiting TNKS1 and TNKS2

Chemical name

rel-4-[(3aR,4S,7R,7aS)-1,3,3a,4,7,7a-Hexahydro-1,3-dioxo-4,7-methano-2H-isoindol-2-yl]-N-8-quinolinylbenzamide

Parent CAS No.

[1127442-82-3]

產(chǎn)品資料