產(chǎn)品名稱 LY 2940680 - Taladegib
產(chǎn)品貨號 Axon 2196 CAS [1258861-20-9] MF C26H24F4N6OMW 512.50 Purity: 99% Soluble in DMSO Description Small-molecule antagonist of the Smoothened (SMO) receptor (IC50 value 2.4 nM), a key signal transducer in the hedgehog signalling pathway, responsible for the maintenance of normal embryonic development and implicated in carcinogenesis. LY 2940680 lacks an undesired inhibitory effect on CYP3A4. References Certificates Categories Extra info C. Wang et al. Structure of the human smoothened receptor bound to an antitumour agent. Nature. 2013, 497, 338-343.? ? P.A. Hipskind et al. Preparation of disubstituted phthalazine derivatives for use as hedgehog pathway antagonists and useful in treatment of cancer. PCT Int. Appl. WO 2010147917 A1 20101223. Certificate of Analysis Material Safety Data Sheet Cell Signaling & Oncology CNS Stem Cell Smoothened (SMO) Hedgehog F Small-molecule antagonist of the Smoothened (SMO) receptor Chemical name 4-fluoro-N-methyl-N-(1-(4-(1-methyl-1H-pyrazol-5-yl)phthalazin-1-yl)piperidin-4-yl)-2-(trifluoromethyl)benzamide Parent CAS No. [1258861-20-9] Order Size Unit Price Stock 5 mg €120.00 In Stock
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LY 2940680 - Taladegib

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 2196

CAS [1258861-20-9]

MF C26H24F4N6O
MW 512.50

  • Purity: 99%
  • Soluble in DMSO

LY 2940680

Description

Small-molecule antagonist of the Smoothened (SMO) receptor (IC50 value 2.4 nM), a key signal transducer in the hedgehog signalling pathway, responsible for the maintenance of normal embryonic development and implicated in carcinogenesis. LY 2940680 lacks an undesired inhibitory effect on CYP3A4.
C. Wang et al. Structure of the human smoothened receptor bound to an antitumour agent. Nature. 2013, 497, 338-343.?
?
P.A. Hipskind et al. Preparation of disubstituted phthalazine derivatives for use as hedgehog pathway antagonists and useful in treatment of cancer. PCT Int. Appl. WO 2010147917 A1 20101223.
Small-molecule antagonist of the Smoothened (SMO) receptor

Chemical name

4-fluoro-N-methyl-N-(1-(4-(1-methyl-1H-pyrazol-5-yl)phthalazin-1-yl)piperidin-4-yl)-2-(trifluoromethyl)benzamide

Parent CAS No.

[1258861-20-9]
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