產(chǎn)品名稱 UNC 569
產(chǎn)品貨號 Axon 2086 CAS [1350547-65-7] MF C22H29FN6MW 396.50 Purity: 99% Soluble in 0.1N HCl(aq) and DMSO Description Potent, reversible and ATP-competitive inhibitor of Mer receptor tyrosine kinase (RTK) (IC50: 2.9 nM). UNC 569 inhibits Mer activation and downstream signaling through ERK1/2 and AKT and was capable of inducing >50% reduction in tumor burden compared to references. Potential therapeutic for acute lymphoblastic leukemia (ALL) and atypical teratoid/rhabdoid tumors (ATRT). KEYWORDS: UNC 569 | supplier | Mer Inhibitor | UNC569 | CAS [1350547-65-7] | Gas6 | Mer | Inhibitor | Receptors | RTK
產(chǎn)品價(jià)格 現(xiàn)貨詢價(jià)，電話：010-67529703
產(chǎn)品規(guī)格
產(chǎn)品品牌 axonmedchem
產(chǎn)品概述
產(chǎn)品詳情

UNC 569

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 2086

CAS [1350547-65-7]

MF C22H29FN6
MW 396.50

  • Purity: 99%
  • Soluble in 0.1N HCl(aq) and DMSO

UNC 569

Description

Potent, reversible and ATP-competitive inhibitor of Mer receptor tyrosine kinase (RTK) (IC50: 2.9 nM). UNC 569 inhibits Mer activation and downstream signaling through ERK1/2 and AKT and was capable of inducing >50% reduction in tumor burden compared to references. Potential therapeutic for acute lymphoblastic leukemia (ALL) and atypical teratoid/rhabdoid tumors (ATRT).

KEYWORDS: UNC 569 | supplier | Mer Inhibitor | UNC569 | CAS [1350547-65-7] | Gas6 | Mer | Inhibitor | Receptors | RTK
產(chǎn)品資料