產品名稱 LBH 589 - NVP-LBH 589 | Panobinostat
產品貨號 Axon 1548 CAS [404950-80-7] MF C21H23N3O2MW 349.43 Purity: 98% Soluble in DMSO Description Highly potent and oral inhibitor of histone deacetylase (HDAC) with IC50 of HDAC1 to be 0.23 nM; an investigational drug against human pancreatic cancer, T cell lymphoma and other types of malignant diseases. In vitro LBH 589 induces cell cycle arrest and apoptosis through both caspase dependent and caspase independent pathways in various tumor cell types at nanomolar concentrations. In vivo LBH 589 inhibits tumor angiogenesis as evidenced by blocking new blood vessel formation in human prostate carcinoma cell PC 3 xenografts References Certificates Categories Extra info P Maiso et al. The Histone Deacetylase Inhibitor LBH589 Is a Potent Antimyeloma Agent that Overcomes Drug Resistance. Cancer Res. 2006, 66(11), 5781-5789.? ? AA Lane and BA Chabner. Histone Deacetylase Inhibitors in Cancer Therapy. J. Clin. Oncol. 2009, 27(32), 5459 - 5468.? ? L Ellis et al. The histone deacetylase inhibitors LAQ824 and LBH589 do not require death receptor signaling or a functional apoptosome to mediate tumor cell death or therapeutic efficacy. Blood, 2009, 114(2), 380 - 393. Certificate of Analysis Material Safety Data Sheet Apoptosis Cell Cycle Regulation Cell Signaling & Oncology Epigenetics DNA-damage Response EC 3.5.1.98 HDAC HDAC1 Inhibitor Chemical name (E)-N-Hydroxy-3-(4-{[2-(2-methyl-1H-indol-3-yl)-ethylamino]-methyl}-phenyl)-acrylamide Parent CAS No. [404950-80-7] Order Size Unit Price Stock 10 mg €95.00 In Stock
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LBH 589 - NVP-LBH 589 | Panobinostat

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 1548

CAS [404950-80-7]

MF C21H23N3O2
MW 349.43

  • Purity: 98%
  • Soluble in DMSO

LBH 589

Description

Highly potent and oral inhibitor of histone deacetylase (HDAC) with IC50 of HDAC1 to be 0.23 nM; an investigational drug against human pancreatic cancer, T cell lymphoma and other types of malignant diseases. In vitro LBH 589 induces cell cycle arrest and apoptosis through both caspase dependent and caspase independent pathways in various tumor cell types at nanomolar concentrations. In vivo LBH 589 inhibits tumor angiogenesis as evidenced by blocking new blood vessel formation in human prostate carcinoma cell PC 3 xenografts
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