產品名稱 GSK 2982772
產品貨號 Axon 2713 CAS [1622848-92-3] MF C20H19N5O3MW 377.40 Purity: 99% Optical purity: Optically pure Soluble in DMSO Description GSK2982772 potently binds to RIP1 with exquisite kinase specificity (IC50 value of 1.0 nM; ADP-Glo activity assay) and has excellent activity in blocking many TNF-dependent cellular responses (IC50 value of 6.3 nM; human monocytic U937 cellular assay). The inhibitor was also able to reduce spontaneous production of cytokines from human ulcerative colitis explants. First-in-class RIP1 inhibitor to enter clinical trials for psoriasis, rheumatoid arthritis, and ulcerative colitis. KEYWORDS: GSK 2982772 | supplier | RIP1 inhibitor | GSK-2982772 | GSK2982772 | CAS [1622848-92-3] | Non Selective (Phosphorylation Substrates) | RIP | Inhibitor | Enzymes
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GSK 2982772

Based on 1 reference(s) in Google Scholar 8 10 1

Axon 2713

CAS [1622848-92-3]

MF C20H19N5O3
MW 377.40

  • Purity: 99%
  • Optical purity: Optically pure
  • Soluble in DMSO

GSK 2982772

Description

GSK2982772 potently binds to RIP1 with exquisite kinase specificity (IC50 value of 1.0 nM; ADP-Glo activity assay) and has excellent activity in blocking many TNF-dependent cellular responses (IC50 value of 6.3 nM; human monocytic U937 cellular assay). The inhibitor was also able to reduce spontaneous production of cytokines from human ulcerative colitis explants. First-in-class RIP1 inhibitor to enter clinical trials for psoriasis, rheumatoid arthritis, and ulcerative colitis.

KEYWORDS: GSK 2982772 | supplier | RIP1 inhibitor | GSK-2982772 | GSK2982772 | CAS [1622848-92-3] | Non Selective (Phosphorylation Substrates) | RIP | Inhibitor | Enzymes
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