產(chǎn)品名稱

Endoxifen

產(chǎn)品貨號

Axon 2190 CAS [110025-28-0] MF C25H27NO2MW 373.49 Purity: 99% Soluble in 0.1N HCl(aq) and DMSO Description Metabolite of Tamoxifen and a selective estrogen receptor modulator (SERM); Potently inhibits the growth of estrogen-stimulated BT474 cells (IC50: 54 nM). Approximately 100-fold more potent as an antagonist of the ERα than the parent drug. Drug for the treatment of estrogen receptor (ER) positive breast cancer.The water soluble hydrochloride salt Endoxifen hydrochloride is available as Axon 2707. KEYWORDS:?Endoxifen | supplier | SERM | CAS [110025-28-0] | Estrogen | Selective Estrogen Receptor Modulator | Nuclear receptor | metabolite | ER positive breast cancer | Tamoxifen

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現(xiàn)貨詢價，電話：010-67529703

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產(chǎn)品品牌

axonmedchem

產(chǎn)品概述

產(chǎn)品詳情

Endoxifen

Based on 14 reference(s) in Google Scholar 8 10 14

Axon 2190

CAS [110025-28-0]

MF C25H27NO2
MW 373.49

Purity: 99%
Soluble in 0.1N HCl(aq) and DMSO

Endoxifen

Description

Metabolite of Tamoxifen and a selective estrogen receptor modulator (SERM); Potently inhibits the growth of estrogen-stimulated BT474 cells (IC50: 54 nM). Approximately 100-fold more potent as an antagonist of the ERα than the parent drug. Drug for the treatment of estrogen receptor (ER) positive breast cancer.
The water soluble hydrochloride salt Endoxifen hydrochloride is available as Axon 2707.

J.R. Hawse et al. Endoxifen’s Molecular Mechanisms of Action Are Concentration Dependent and Different than That of Other Anti-Estrogens. PLoS One. 2013, 8, e54613.?

A Ahmad et al. Endoxifen, a New Cornerstone of Breast Cancer Therapy: Demonstration of Safety, Tolerability, and Systemic Bioavailability in Healthy Human Subjects. Clin. Pharmacol. Ther. 2010, 88(6), 814–817.?

M.D. Johnson et al. Pharmacological Characterization of 4-hydroxy-N-desmethyl Tamoxifen, a Novel Active Metabolite of Tamoxifen. Breast Cancer Research and Treatment 2004, 85, 151-159.?

M. Goetz et al. Tamoxifen, HER2, and Endoxifen: The Role of CYP2D6 as a Predictor of Tamoxifen Resistance in ER+/HER2+ Breast Cancer. Cancer Res 2009, 69, Abstract nr 2006 (S3).?

Certificate of Analysis
Material Safety Data Sheet

Cell Signaling & Oncology Endocrinology Estrogen (ER) NR3A

Selective estrogen receptor modulator (SERM)

Chemical name

(E/Z)-4-(1-(4-(2-(methylamino)ethoxy)phenyl)-2-phenylbut-1-enyl)phenol

Parent CAS No.

[110025-28-0]

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