產(chǎn)品名稱

ITD 1

產(chǎn)品貨號(hào)

Axon 2323 CAS [1099644-42-4] MF C27H29NO3MW 415.52 Purity: 98% Soluble in DMSO Description Selective inhibitor of TGFβ/Smad signaling (IC50 value 0.85 μM; 83% TGF-β inhibiton at 2.5 μM) that acts by clearing the type II TGFβ receptor from the cell surface. ITD1 stimulates the differentiation of cardiomyocytes and promote cardiogenesis in murine embryonic stem cell (mESCs). TGFβ inhibition by the (+)-eneatiomer is approximately 15-fold more effective than by its (?)-enantiomer. Note

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axonmedchem

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產(chǎn)品詳情

ITD 1

Based on 18 reference(s) in Google Scholar 9 10 18

Axon 2323

CAS [1099644-42-4]

MF C27H29NO3
MW 415.52

Purity: 98%
Soluble in DMSO

ITD 1

Description

Selective inhibitor of TGFβ/Smad signaling (IC50 value 0.85 μM; 83% TGF-β inhibiton at 2.5 μM) that acts by clearing the type II TGFβ receptor from the cell surface. ITD1 stimulates the differentiation of cardiomyocytes and promote cardiogenesis in murine embryonic stem cell (mESCs). TGFβ inhibition by the (+)-eneatiomer is approximately 15-fold more effective than by its (?)-enantiomer.

Note: The optically pure (+)-ITD 1 (Axon 2467) is available as well

D. Schade et al. Synthesis and SAR of b-annulated 1,4-dihydropyridines define cardiomyogenic compounds as novel inhibitors of TGFβ signaling. J. Med. Chem. 2012, 55, 9946-9957.

E. Willems et al. Small molecule-mediated TGF-β type II receptor degradation promotes cardiomyogenesis in embryonic stem cells. Cell Stem Cell. 2012, 11, 242-252.

Certificate of Analysis
Material Safety Data Sheet

Apoptosis Cell Signaling & Oncology Stem Cell TGF-β RSTK class II; EC 2.7.11.30 Stem Cell Differentiator TGF-βR

Selective inhibitor of TGFβ/Smad signaling that promotes cardiogenesis

Chemical name

ethyl 4-(biphenyl-4-yl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate

Parent CAS No.

[1099644-42-4]

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