產(chǎn)品名稱 Azoramide
產(chǎn)品貨號(hào) Axon 2567 CAS [932986-18-0] MF C15H17ClN2OSMW 308.83 Purity: 99% Soluble in DMSO Description Small-molecule modulator of the unfolded protein response (UPR) with antidiabetic activity (IC50 value 8.826 μM for azoramide-induced increase of ASGR-Cluc secretion in HuH7 cells). Azoramide is a dual-function ER modulator that improves ER protein-folding ability and activates ER chaperone capacity to protect cells against ER stress. Moreover, Azoramide improves insulin sensitivity and pancreatic β-cell function in multiple obese mouse preclinical models. KEYWORDS: Azoramide | supplier | UPR modulator | CAS [932986-18-0] | Unfolded Protein Response | endoplasmatic reticulum | ER stress | protein folding | PERK | IRE1 | ATF6 | obesity | antidiabetic | glucose
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產(chǎn)品品牌 axonmedchem
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Azoramide

Based on 31 reference(s) in Google Scholar 9 10 31

Axon 2567

CAS [932986-18-0]

MF C15H17ClN2OS
MW 308.83

  • Purity: 99%
  • Soluble in DMSO

Azoramide

Description

Small-molecule modulator of the unfolded protein response (UPR) with antidiabetic activity (IC50 value 8.826 μM for azoramide-induced increase of ASGR-Cluc secretion in HuH7 cells). Azoramide is a dual-function ER modulator that improves ER protein-folding ability and activates ER chaperone capacity to protect cells against ER stress. Moreover, Azoramide improves insulin sensitivity and pancreatic β-cell function in multiple obese mouse preclinical models.

KEYWORDS: Azoramide | supplier | UPR modulator | CAS [932986-18-0] | Unfolded Protein Response | endoplasmatic reticulum | ER stress | protein folding | PERK | IRE1 | ATF6 | obesity | antidiabetic | glucose
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