產(chǎn)品名稱(chēng) FH535 sodium salt
產(chǎn)品貨號(hào) Axon 2706 CAS [N.A.] MF C13H9Cl2N2NaO4SMW 383.18 Purity: 99% Soluble in water and DMSO Description Small-molecule dual inhibitor of peroxisome proliferator-activated receptor (PPAR) and Wnt/β-catenin/TCF/LEF signaling. FH535 inhibits recruitment of the coactivators β-catenin and GRIP1, but not the corepressors NCoR and SMRT. FH535 is selectively toxic to carcinomas expressing the Wnt/β-Catenin pathway, and known to inhibit invasion, migration, and growth in vitro in multiple types of cancer, such as liver cancer and triple negative breast cancer cell lines; water soluble sodium salt form of FH535 (Axon 2686). KEYWORDS: FH535 sodium salt | supplier | Dual Wnt/β-catenin and PPAR inhibitor | FH-535 sodium salt | FH 535 sodium salt | CAS [108409-83-2] | Metabolism | PPARγ | PPARδ | peroxisome proliferator–activated receptor | Nuclear | NR1C | Tcf/Lef
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FH535 sodium salt

Based on 3 reference(s) in Google Scholar 9 10 3

Axon 2706

CAS [N.A.]

MF C13H9Cl2N2NaO4S
MW 383.18

  • Purity: 99%
  • Soluble in water and DMSO

FH535 sodium salt

Description

Small-molecule dual inhibitor of peroxisome proliferator-activated receptor (PPAR) and Wnt/β-catenin/TCF/LEF signaling. FH535 inhibits recruitment of the coactivators β-catenin and GRIP1, but not the corepressors NCoR and SMRT. FH535 is selectively toxic to carcinomas expressing the Wnt/β-Catenin pathway, and known to inhibit invasion, migration, and growth in vitro in multiple types of cancer, such as liver cancer and triple negative breast cancer cell lines; water soluble sodium salt form of FH535 (Axon 2686).

KEYWORDS: FH535 sodium salt | supplier | Dual Wnt/β-catenin and PPAR inhibitor | FH-535 sodium salt | FH 535 sodium salt | CAS [108409-83-2] | Metabolism | PPARγ | PPARδ | peroxisome proliferator–activated receptor | Nuclear | NR1C | Tcf/Lef
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